N-Depropyl N-Benzyl Propafenone

Base Information

• Chemical Name: N-Depropyl N-Benzyl Propafenone
• CAS No.: 178691-47-9
• Molecular Formula: C₂₅H₂₇NO₃
• Molecular Weight: 389.494
• Mol file: 178691-47-9.mol

Synonyms:N-Depropyl N-Benzyl Propafenone;

Chemical Property of N-Depropyl N-Benzyl Propafenone

Chemical Property:

• PSA: 58.56000
• LogP: 4.42250
• Solubility.: Ethanol, Methanol

Purity/Quality:

N-Depropyl N-Benzyl Propafenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Depropyl N-Benzyl Propafenone is used in the preparation of Propafenone analogues as antimalarial agents.

Technology Process of N-Depropyl N-Benzyl Propafenone

There total 2 articles about N-Depropyl N-Benzyl Propafenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one (22525-95-7) + benzylamine (100-46-9) → 1-(2-(3-benzylamino-2-hydroxypropoxy)phenyl)-3-phenyl-1-propanone (178691-47-9)

Guidance literature:

for 6h; Heating;

DOI:10.1021/jm960384x

Reference yield:

2'-hydroxy-3-phenylpropiophenone (3516-95-8) → 1-(2-(3-benzylamino-2-hydroxypropoxy)phenyl)-3-phenyl-1-propanone (178691-47-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH

2: 65 percent / 6 h / Heating

With sodium hydroxide;

DOI:10.1021/jm960384x

Reference yield: 42.7%

propionyl chloride (79-03-8) + 1-(2-(3-benzylamino-2-hydroxypropoxy)phenyl)-3-phenyl-1-propanone (178691-47-9) → N-benzyl-N-(3-(2-(1-oxo-3-phenylpropyl)phenoxy)-2-hydroxypropyl)propionic acid amide

Guidance literature:

With pyridine; for 2h;

upstream raw materials:

1-(2-(oxiran-2-ylmethoxy)phenyl)-3-phenylpropan-1-one

benzylamine

2'-hydroxy-3-phenylpropiophenone