Acetic acid, [[8-[[2,6-dichloro-3-[methyl[[[(2E)-3-[4-[(methylamino)carbonyl]phenyl]-1- oxo-2-propenyl]amino]acetyl]amino]phenyl]methoxy]-2-methyl-4-quinolin yl]oxy]-, ethyl ester

Base Information

Chemical Name:Acetic acid, [[8-[[2,6-dichloro-3-[methyl[[[(2E)-3-[4-[(methylamino)carbonyl]phenyl]-1- oxo-2-propenyl]amino]acetyl]amino]phenyl]methoxy]-2-methyl-4-quinolin yl]oxy]-, ethyl ester
CAS No.:179622-66-3
Molecular Formula:C35H34Cl2N4O7
Molecular Weight:693.584
Hs Code.:
Mol file:179622-66-3.mol

Acetic acid,
[[8-[[2,6-dichloro-3-[methyl[[[(2E)-3-[4-[(methylamino)carbonyl]phenyl]-1-
oxo-2-propenyl]amino]acetyl]amino]phenyl]methoxy]-2-methyl-4-quinolin
yl]oxy]-, ethyl ester

Synonyms:

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Chemical Property of Acetic acid, [[8-[[2,6-dichloro-3-[methyl[[[(2E)-3-[4-[(methylamino)carbonyl]phenyl]-1- oxo-2-propenyl]amino]acetyl]amino]phenyl]methoxy]-2-methyl-4-quinolin yl]oxy]-, ethyl ester

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Purity/Quality:

Safty Information:

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Technology Process of Acetic acid, [[8-[[2,6-dichloro-3-[methyl[[[(2E)-3-[4-[(methylamino)carbonyl]phenyl]-1- oxo-2-propenyl]amino]acetyl]amino]phenyl]methoxy]-2-methyl-4-quinolin yl]oxy]-, ethyl ester

There total 6 articles about Acetic acid, [[8-[[2,6-dichloro-3-[methyl[[[(2E)-3-[4-[(methylamino)carbonyl]phenyl]-1- oxo-2-propenyl]amino]acetyl]amino]phenyl]methoxy]-2-methyl-4-quinolin yl]oxy]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.8%

: 177477-93-9
2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl)cinnamoylglycyl)amino]benzyl bromide

: 179626-85-8
ethyl [(8-hydroxy-2-methyl-4-quinolinyl)oxy]acetate

: 179622-66-3
ethyl [(8-{[2,6-dichloro-3-(methyl{[((2E)-3-{4-[(methylamino)carbonyl]phenyl}-2-propenoyl)amino]acetyl}amino)benzyl]oxy}-2-methyl-4-quinolinyl)oxy]acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm030468n

Reference yield:

: 20012-63-9
o-(benzyloxy)aniline

: 179622-66-3
ethyl [(8-{[2,6-dichloro-3-(methyl{[((2E)-3-{4-[(methylamino)carbonyl]phenyl}-2-propenoyl)amino]acetyl}amino)benzyl]oxy}-2-methyl-4-quinolinyl)oxy]acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 89.3 percent / AcOH / benzene / 6 h / Heating

2: 24.8 percent / diphenyl ether; various solvent(s) / 1.25 h / 230 - 235 °C

3: 73.9 percent / K₂CO₃ / dimethylformamide / 4 h / 20 °C

4: 55.8 percent / H₂ / Pd/C / ethanol; dioxane / 20 °C

5: 73.8 percent / K₂CO₃ / dimethylformamide / 20 °C

With hydrogen; potassium carbonate; acetic acid; palladium on activated charcoal; In 1,4-dioxane; diphenylether; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm030468n

Reference yield:

: 179626-83-6
8-(benzyloxy)-2-methyl-4-quinolinol

: 179622-66-3
ethyl [(8-{[2,6-dichloro-3-(methyl{[((2E)-3-{4-[(methylamino)carbonyl]phenyl}-2-propenoyl)amino]acetyl}amino)benzyl]oxy}-2-methyl-4-quinolinyl)oxy]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 73.9 percent / K₂CO₃ / dimethylformamide / 4 h / 20 °C

2: 55.8 percent / H₂ / Pd/C / ethanol; dioxane / 20 °C

3: 73.8 percent / K₂CO₃ / dimethylformamide / 20 °C

With hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm030468n