4-Carboxymethoxy-8-[2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl)cinnamoylglycyl]amino]benzyloxy]-2-methylquinoline

Base Information

Chemical Name:4-Carboxymethoxy-8-[2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl)cinnamoylglycyl]amino]benzyloxy]-2-methylquinoline
CAS No.:179622-68-5
Molecular Formula:C₃₃H₃₀Cl₂N₄O₇
Molecular Weight:665.53
Hs Code.:

Synonyms:4-Carboxymethoxy-8-[2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl)cinnamoylglycyl]amino]benzyloxy]-2-methylquinoline

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Chemical Property of 4-Carboxymethoxy-8-[2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl)cinnamoylglycyl]amino]benzyloxy]-2-methylquinoline

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Technology Process of 4-Carboxymethoxy-8-[2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl)cinnamoylglycyl]amino]benzyloxy]-2-methylquinoline

There total 7 articles about 4-Carboxymethoxy-8-[2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl)cinnamoylglycyl]amino]benzyloxy]-2-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.9%

: 179622-66-3
ethyl [(8-{[2,6-dichloro-3-(methyl{[((2E)-3-{4-[(methylamino)carbonyl]phenyl}-2-propenoyl)amino]acetyl}amino)benzyl]oxy}-2-methyl-4-quinolinyl)oxy]acetate

: 179622-68-5
4-Carboxymethoxy-8-[2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl)cinnamoylglycyl]amino]benzyloxy]-2-methylquinoline

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃; for 2h;
DOI:10.1021/jm030468n

Reference yield:

: 20012-63-9
o-(benzyloxy)aniline

: 179622-68-5
4-Carboxymethoxy-8-[2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl)cinnamoylglycyl]amino]benzyloxy]-2-methylquinoline

Guidance literature:: Multi-step reaction with 6 steps

1: 89.3 percent / AcOH / benzene / 6 h / Heating

2: 24.8 percent / diphenyl ether; various solvent(s) / 1.25 h / 230 - 235 °C

3: 73.9 percent / K₂CO₃ / dimethylformamide / 4 h / 20 °C

4: 55.8 percent / H₂ / Pd/C / ethanol; dioxane / 20 °C

5: 73.8 percent / K₂CO₃ / dimethylformamide / 20 °C

6: 88.9 percent / aq. NaOH / ethanol / 2 h / 20 °C

With sodium hydroxide; hydrogen; potassium carbonate; acetic acid; palladium on activated charcoal; In 1,4-dioxane; diphenylether; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm030468n

Reference yield:

: 179626-83-6
8-(benzyloxy)-2-methyl-4-quinolinol

: 179622-68-5
4-Carboxymethoxy-8-[2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl)cinnamoylglycyl]amino]benzyloxy]-2-methylquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 73.9 percent / K₂CO₃ / dimethylformamide / 4 h / 20 °C

2: 55.8 percent / H₂ / Pd/C / ethanol; dioxane / 20 °C

3: 73.8 percent / K₂CO₃ / dimethylformamide / 20 °C

4: 88.9 percent / aq. NaOH / ethanol / 2 h / 20 °C

With sodium hydroxide; hydrogen; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm030468n