Technology Process of Pentanoic acid, 2-hydroxy-3-methyl-, phenylmethyl ester, (2R,3R)-
There total 2 articles about Pentanoic acid, 2-hydroxy-3-methyl-, phenylmethyl ester, (2R,3R)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 20h;
Inert atmosphere;
Schlenk technique;
DOI:10.1021/acs.jmedchem.9b01457
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sulfuric acid; sodium nitrite / water / 19.25 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
2: caesium carbonate / N,N-dimethyl-formamide / 20 h / 0 - 20 °C / Inert atmosphere; Schlenk technique
With
sulfuric acid; caesium carbonate; sodium nitrite;
In
water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.9b01457
- Guidance literature:
-
Multi-step reaction with 9 steps
1: dicyclohexylcarbodiimide (DCC), DMAP
2: H2 / 10percent Pd/C
3: N-methylmorpholine (NMM), bis(2-oxo-3-oxazolidinyl)phosphinic chloride (Bop-Cl)
4: 50percent TFA / CH2Cl2
7: H2 / 10percent Pd/C
8: 1.) 50percent TFA; 2.) 1N HCl / 1.) CH2Cl2
9: benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP), DMAP / CH2Cl2
With
4-methyl-morpholine; hydrogenchloride; dmap; hydrogen; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium on activated charcoal;
In
dichloromethane;
DOI:10.1016/0040-4039(96)01199-9
