4-(Cbz-amino)-1-benzylpiperidine

Base Information

Chemical Name:4-(Cbz-amino)-1-benzylpiperidine
CAS No.:182223-53-6
Molecular Formula:C20H24N2O2
Molecular Weight:324.423
Hs Code.:2933399090
DSSTox Substance ID:DTXSID00443559
Mol file:182223-53-6.mol

Synonyms:4-(Cbz-amino)-1-benzylpiperidine;182223-53-6;benzyl N-(1-benzylpiperidin-4-yl)carbamate;Benzyl (1-Benzylpiperidin-4-yl)carbamate;1-BENZYL-4-BENZYLOXYCARBONYLAMINOPIPERIDINE;p38 inhibitor;MFCD16251209;Carbamic acid, [1-(phenylmethyl)-4-piperidinyl]-, phenylmethyl ester;SCHEMBL5122686;DTXSID00443559;AMY20315;AKOS022183960;AS-31948;SY017014;CS-0058717;FT-0662694;EN300-7093630;A880918;Carbamic acid, [1-(phenylmethyl)-4-piperidinyl]-, phenylmethyl ester (9CI)

Suppliers and Price of 4-(Cbz-amino)-1-benzylpiperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
1-Benzyl-4-benzyloxycarbonylaminopiperidine
250mg
$ 446.00

TRC
1-Benzyl-4-benzyloxycarbonylaminopiperidine
250mg
$ 105.00

TRC
1-Benzyl-4-benzyloxycarbonylaminopiperidine
500mg
$ 135.00

TRC
1-Benzyl-4-benzyloxycarbonylaminopiperidine
1g
$ 255.00

Crysdot
Benzyl(1-benzylpiperidin-4-yl)carbamate 95+%
10g
$ 468.00

Crysdot
Benzyl(1-benzylpiperidin-4-yl)carbamate 95+%
25g
$ 855.00

Chemenu
Benzyl(1-benzylpiperidin-4-yl)carbamate 95%
10g
$ 438.00

Chemenu
Benzyl(1-benzylpiperidin-4-yl)carbamate 95%
25g
$ 800.00

Biosynth Carbosynth
1-Benzyl-4-benzyloxycarbonylaminopiperidine
1 g
$ 462.50

Biosynth Carbosynth
1-Benzyl-4-benzyloxycarbonylaminopiperidine
2 g
$ 840.90

Total 9 raw suppliers

Chemical Property of 4-(Cbz-amino)-1-benzylpiperidine

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:77-78°C
Boiling Point:475.75oC at 760 mmHg
PKA:12.14±0.20(Predicted)
Flash Point:241.525oC
PSA：45.06000
Density:1.158g/cm3
LogP:3.71970
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:324.183778013
Heavy Atom Count:24
Complexity:368

Purity/Quality:

97% ^*data from raw suppliers

1-Benzyl-4-benzyloxycarbonylaminopiperidine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1NC(=O)OCC2=CC=CC=C2)CC3=CC=CC=C3
Recent ClinicalTrials:A Study of P38 Inhibitor (4) Monotherapy in Patients With Active Rheumatoid Arthritis
Uses As a intermediate, 1-Benzyl-4-benzyloxycarbonylaMinopiperidine can be used in the preparation p-38 kinase inhibitors and serotonin antagonists.

Technology Process of 4-(Cbz-amino)-1-benzylpiperidine

There total 1 articles about 4-(Cbz-amino)-1-benzylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 50541-93-0
4-amino-1-benzylpiperidine

: 501-53-1,94274-21-2
benzyl chloroformate

: 182223-53-6
benzyl 1-benzylpiperidin-4-ylcarbamate

Guidance literature:: With sodium hydroxide; In dichloromethane; for 0.333333h; Ambient temperature;
DOI:10.1021/jm970857f

Reference yield:

: 182223-53-6
benzyl 1-benzylpiperidin-4-ylcarbamate

: 182223-54-7
piperidin-4-ylcarbamic acid benzyl ester

Guidance literature:: With carbonochloridic acid 1-chloro-ethyl ester; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 182223-53-6
benzyl 1-benzylpiperidin-4-ylcarbamate

: 1-Isopropyl-1H-indazole-3-carboxylic acid [2-(4-benzoylamino-piperidin-1-yl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) 1-chloroethyl chloroformate / 1.) CH₂Cl₂, RT, 1 h, 2.) MeOH, reflux, 1 h

2: 51 percent / Na₂CO₃ / dimethylformamide / 18 h / 100 °C

3: hydrazine hydrate / ethanol / 4 h / Heating

4: 1.) 1,1'-carbonyldiimidazole / 1.) DMF, RT, 4 h, 2.) DMF, RT, 18 h

5: 1.) NaH / 1.) DMF, RT, 4 h, 2.) DMF, RT, 18 h

6: 81 percent / H₂ / 5percent Pd/C / ethanol / 18 h / 3102.9 Torr / Ambient temperature

7: Et₃N / tetrahydrofuran

With carbonochloridic acid 1-chloro-ethyl ester; hydrogen; sodium hydride; sodium carbonate; hydrazine hydrate; triethylamine; 1,1'-carbonyldiimidazole; palladium on activated charcoal; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm970857f