4-Cbz-aminopiperidine

Base Information

• Chemical Name: 4-Cbz-aminopiperidine
• CAS No.: 207296-89-7
• Molecular Formula: C13H19ClN2O2
• Molecular Weight: 270.75516
• Hs Code.: 2933399090
• European Community (EC) Number: 800-495-0,853-262-0
• DSSTox Substance ID: DTXSID00363849
• Wikidata: Q72515984
• Mol file: 207296-89-7.mol

Synonyms:4-Cbz-aminopiperidine;182223-54-7;4-Benzyloxycarbonylamino-piperidine;benzyl N-(piperidin-4-yl)carbamate;benzyl N-piperidin-4-ylcarbamate;BENZYL PIPERIDIN-4-YLCARBAMATE;4-(Cbz-amino)piperidine;MFCD04038571;4-(CBZ-AMINO)-PIPERIDINE;Carbamic acid, 4-piperidinyl-, phenylmethyl ester;4-Benzyloxycarbonylaminopiperidine;4-(Benzyloxycarbonylamino)piperidine;Benzyl piperidin-4-ylcarbamate;N-CBZ-4-aminepiperidin;4-(Z-amino)-piperidine;SCHEMBL7617;Benzyl 4-piperidinylcarbamate;Carbamic acid, N-4-piperidinyl-, phenylmethyl ester;Benzyl piperidin-4-yl-carbamate;DTXSID00363849;CHEBI:191071;SC3411;AKOS015911512;AC-1495;AM85322;CS-W008988;AS-18171;piperidin-4-yl-carbamic acid benzyl ester;SY030871;FT-0649335;EN300-156580;benzyl piperidin-4-ylcarbamate

Chemical Property of 4-Cbz-aminopiperidine

Chemical Property:

• PSA: 53.85000
• LogP: 3.00000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly)
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 234.136827821
• Heavy Atom Count: 17
• Complexity: 234

Purity/Quality:

98% ^*data from raw suppliers

4-Cbz-aminopiperidine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNCCC1NC(=O)OCC2=CC=CC=C2
• Uses: 4-Benzyloxycarbonylaminopiperidine Hydrochloride is used in the preparation of certain antibiotics, p-38 kinase inhibitors, and serotonin antagonists.

Technology Process of 4-Cbz-aminopiperidine

There total 6 articles about 4-Cbz-aminopiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)piperidine (220394-97-8) → piperidin-4-ylcarbamic acid benzyl ester hydrochloride (207296-89-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 5h;

Reference yield:

4-amino-1-benzylpiperidine (50541-93-0) → piperidin-4-ylcarbamic acid benzyl ester hydrochloride (207296-89-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / 1N aq. NaOH / CH₂Cl₂ / 0.33 h / Ambient temperature

2: 1.) 1-chloroethyl chloroformate / 1.) CH₂Cl₂, RT, 1 h, 2.) MeOH, reflux, 1 h

With sodium hydroxide; carbonochloridic acid 1-chloro-ethyl ester; In dichloromethane;

DOI:10.1021/jm970857f

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → piperidin-4-ylcarbamic acid benzyl ester hydrochloride (207296-89-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / 1N aq. NaOH / CH₂Cl₂ / 0.33 h / Ambient temperature

2: 1.) 1-chloroethyl chloroformate / 1.) CH₂Cl₂, RT, 1 h, 2.) MeOH, reflux, 1 h

With sodium hydroxide; carbonochloridic acid 1-chloro-ethyl ester; In dichloromethane;

DOI:10.1021/jm970857f

upstream raw materials:

benzyl 1-benzylpiperidin-4-ylcarbamate

4-amino-1-benzylpiperidine

benzyl chloroformate

4-(benzyloxycarbonylamino)-1-(tert-butoxycarbonyl)piperidine