3-Formyl-4-hydroxyphenylboronic acid

Base Information

• Chemical Name: 3-Formyl-4-hydroxyphenylboronic acid
• CAS No.: 182344-24-7
• Molecular Formula: C7H7BO4
• Molecular Weight: 165.941
• Hs Code.: 2931900090
• Mol file: 182344-24-7.mol

Synonyms:

Chemical Property of 3-Formyl-4-hydroxyphenylboronic acid

Chemical Property:

• Boiling Point: 367.6±52.0 °C(Predicted)
• PKA: 7.87±0.31(Predicted)
• PSA: 77.76000
• Density: 1.40±0.1 g/cm3(Predicted)
• LogP: -1.11550

Purity/Quality:

99% ^*data from raw suppliers

3-Formyl-4-hydroxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Formyl-4-hydroxyphenylboronic acid

There total 2 articles about 3-Formyl-4-hydroxyphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

tetrahydroxydiboron (13675-18-8) + 5-bromosalicyclaldehyde (1761-61-1) → 3-formyl-4-hydroxyphenylboronic acid (182344-24-7)

Guidance literature:

With palladium diacetate; KOAc; XPhos; In ethanol; for 1h; Inert atmosphere; Heating;

DOI:10.3390/molecules25040781

Reference yield: 43.0%

Trimethyl borate (121-43-7,63156-11-6) + 5-bromosalicylaldehyde dimethyl acetal (501085-54-7) → 3-formyl-4-hydroxyphenylboronic acid (182344-24-7)

Guidance literature:

Trimethyl borate; 5-bromosalicylaldehyde dimethyl acetal; With n-butyllithium; In diethyl ether; hexane; at -95 - 25 ℃; for 3h;

With hydrogenchloride; water; In diethyl ether; hexane; at 20 ℃; pH=1.0;

Reference yield: 75.0%

8-(methylthio)-4,4,difluoro-4-bora-3a,4a-diaza-s-indacene + 3-formyl-4-hydroxyphenylboronic acid (182344-24-7) → C16H11BF2N2O2

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; trifuran-2-yl-phosphane; In tetrahydrofuran; at 55 ℃; for 2h; Inert atmosphere;

DOI:10.3390/molecules25040781

upstream raw materials:

Trimethyl borate

5-bromosalicylaldehyde dimethyl acetal

tetrahydroxydiboron

5-bromosalicyclaldehyde

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS AS TYROSINE KINASE MODULATORS". Page/Page column 311-312. . Retrieved 2010/11/27.