(S)-2-Amino-6-hydroxyhexanoic acid

Base Information

Chemical Name:(S)-2-Amino-6-hydroxyhexanoic acid
CAS No.:305-77-1
Molecular Formula:C₆H₁₃NO₃
Molecular Weight:147.174
Hs Code.:
UNII:874D12O72W
Nikkaji Number:J977.779B
Wikidata:Q27096308
ChEMBL ID:CHEMBL1233976
Mol file:305-77-1.mol

Synonyms:2-amino-6-hydroxycaproic acid;6-hydroxy-2-aminocaproic acid;alpha-amino-epsilon-hydroxycaproic acid;epsilon-hydroxynorleucine;epsilon-hydroxynorleucine, (DL)-isomer;epsilon-hydroxynorleucine, (L)-isomer;HACA cpd

Suppliers and Price of (S)-2-Amino-6-hydroxyhexanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
DL-6-Hydroxy norleucine
1mg
$ 668.00

TRC
DL-6-HydroxyNorleucine
500mg
$ 185.00

Medical Isotopes, Inc.
DL-6-HydroxyNorleucine
12.5 mg
$ 2120.00

Crysdot
2-Amino-6-hydroxyhexanoicacid 95+%
1g
$ 772.00

Chemenu
2-amino-6-hydroxyhexanoicacid 95%
1g
$ 729.00

Total 14 raw suppliers

Chemical Property of (S)-2-Amino-6-hydroxyhexanoic acid

Chemical Property:

Melting Point:245-262 °C
Boiling Point:361.7°Cat760mmHg
PKA:2.53±0.24(Predicted)
Flash Point:172.6°C
PSA：83.55000
Density:1.189g/cm³
LogP:0.26120
Storage Temp.:2-8°C
Solubility.:Aqueous Acid (Slightly), Water (Slightly)
XLogP3:-2.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:147.08954328
Heavy Atom Count:10
Complexity:105

Purity/Quality:

98% ^*data from raw suppliers

DL-6-Hydroxy norleucine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C(CCO)CC(C(=O)O)N
Isomeric SMILES:C(CCO)C[C@@H](C(=O)O)N
Uses An intermediate for antiviral and antihypertensive drugs An intermediate for antiviral and antihypertensive drugs.

Technology Process of (S)-2-Amino-6-hydroxyhexanoic acid

There total 1 articles about (S)-2-Amino-6-hydroxyhexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 5462-80-6
rac-6-hydroxynorleucine

: 305-77-1,5462-80-6,6033-32-5,16509-61-8
L-ε-hydroxynorleucine

Guidance literature:: DOI:10.1021/jo00326a061

Reference yield: 80.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 305-77-1,5462-80-6,6033-32-5,16509-61-8
L-ε-hydroxynorleucine

: 77611-37-1,81505-64-8
α-N-(tert-butoxycarbonyl)-L-ε-hydroxynorleucine

Guidance literature:: With triethylamine; In tetrahydrofuran; water; Ambient temperature; overnight;
DOI:10.1021/jo00326a061

Reference yield:

: 305-77-1,5462-80-6,6033-32-5,16509-61-8
L-ε-hydroxynorleucine

: 77611-38-2,84063-93-4
(1-Benzyloxycarbamoyl-5-hydroxy-pentyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Et₃N / tetrahydrofuran; H₂O / Ambient temperature; overnight

2: 80 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide / H₂O / 0.5 h / Ambient temperature; pH 4.5

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; water;
DOI:10.1021/jo00326a061