ethyl-2-bromo-4-methoxyphenylacetate

Base Information

• Chemical Name: ethyl-2-bromo-4-methoxyphenylacetate
• CAS No.: 77053-56-6
• Molecular Formula: C₁₁H₁₃BrO₃
• Molecular Weight: 273.126
• Mol file: 77053-56-6.mol

Synonyms:Aceticacid, bromo(p-methoxyphenyl)-, ethyl ester (6CI,7CI); Ethyl2-bromo-2-(4-methoxyphenyl)acetate; Ethyl bromo(4-methoxyphenyl)acetate; Ethyl a-bromo-4-methoxyphenylacetate; a-Bromo-4-methoxybenzeneaceticacid ethyl ester; a-Bromo-a-(p-methoxyphenyl)aceticacid ethyl ester

Chemical Property of ethyl-2-bromo-4-methoxyphenylacetate

Chemical Property:

• Vapor Pressure: 0.000394mmHg at 25°C
• Boiling Point: 317.1°C at 760 mmHg
• Flash Point: 145.6°C
• Density: 1.388g/cm³

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl-2-bromo-4-methoxyphenylacetate

There total 10 articles about ethyl-2-bromo-4-methoxyphenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl p-methoxyphenylacetate (14062-18-1) → ethyl 2-bromo-2-(4-methoxyphenyl) acetate (77629-83-5,77053-56-6)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 3h; Heating;

DOI:10.1021/ol052118w

Reference yield: 92.0%

ethyl 2-hydroxy-2-(4-methoxyphenyl)acetate (36141-66-9) → ethyl 2-bromo-2-(4-methoxyphenyl) acetate (77629-83-5,77053-56-6)

Guidance literature:

With phosphorus tribromide; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1055/s-2006-942404

Reference yield: 81.0%

ethyl 2-diazo-2-(4-methoxyphenyl) acetate (107445-17-0) → ethyl 2-bromo-2-(4-methoxyphenyl) acetate (77629-83-5,77053-56-6)

Guidance literature:

With cobalt(II) bromide hexahydrate; In 1,4-dioxane; at 100 ℃; for 0.666667h; Inert atmosphere;

DOI:10.1002/adsc.202000009

upstream raw materials:

ethyl p-methoxyphenylacetate

4-methoxyphenylboronic acid

ethyl bromoacetate

ethyl 2-hydroxy-2-(4-methoxyphenyl)acetate

Downstream raw materials:

1-<2-(α-hydroxycarbonyl-p-methoxybenzyl)thiophenyl>pyrrole

meso-2,3-bis-(4-methoxy-phenyl)-succinic acid diethyl ester

Refernces

• 1、 Wang, Haifeng,Sun, Xiangli,Hu, Manman,Zhang, Xiaoyi,Xie, Lele,Gu, Shuangxi. "Bromination of α-Diazo Phenylacetate Derivatives Using Cobalt(II) Bromide". supporting information. p. 3347 - 3351. Retrieved 2020/07/04.
• 2、 Tang, Shi,Yang, Sheng-Wen,Sun, Hongwei,Zhou, Yali,Li, Juan,Zhu, Qiang. "Pd-catalyzed divergent C(sp2)-H Activation/Cycloimidoylation of 2-Isocyano-2,3-diarylpropanoates". supporting information. p. 1832 - 1836. Retrieved 2018/04/14.