36141-66-9

Basic information

• Product Name: ethyl 2-hydroxy-2-(4-methoxyphenyl)acetate
• Synonyms: ethyl 2-hydroxy-2-(4-methoxyphenyl)acetate
• CAS NO: 36141-66-9
• Molecular Weight: 210.23
• Mol File: 36141-66-9.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: ethyl 2-hydroxy-2-(4-methoxyphenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-hydroxy-2-(4-methoxyphenyl)acetate(36141-66-9)
• EPA Substance Registry System: ethyl 2-hydroxy-2-(4-methoxyphenyl)acetate(36141-66-9)

Safety Data

• Hazardous Substances Data: 36141-66-9(Hazardous Substances Data)

Upstream product

• 33646-40-1 4-methoxymandelonitrile 
• 40140-16-7 ethyl (p-methoxyphenyl)oxoacetate 
• 34006-60-5 ethyl 2-chloro-2-ethoxyacetate 
• 100-66-3 methoxybenzene 
• 64-17-5 ethanol 
• 20714-90-3 4-Methoxymandelic acid 
• 14062-18-1 ethyl p-methoxyphenylacetate 
• 67-56-1 methanol 
• 136878-05-2 α-(ethoxycarbonyl)-4-methoxybenzyl alcohol pentafluorobenzoate ester 
• 1076-95-5 p-methoxyphenylglyoxal 
• 925-61-1 n-propyl glyoxylate 
• 924-44-7 glyoxylic acid ethyl ester 
• 5720-07-0 4-methoxyphenylboronic acid 
• 107445-17-0 ethyl 2-diazo-2-(4-methoxyphenyl) acetate 

Downstream Products

• 261930-06-7 1-(4-methoxyphenyl)-1,2-dihydroxy-2-methylpropane 
• 855244-11-0 2-ethyl-1-(4-methoxy-phenyl)-butane-1,2-diol 
• 4237-52-9 2-(4-methoxyphenyl)-1,1-diphenylethane-1,2-diol 
• 20714-90-3 4-Methoxymandelic acid 
• 88920-25-6 ethoxy-p-methoxyphenylacetic acid 
• 136878-05-2 α-(ethoxycarbonyl)-4-methoxybenzyl alcohol pentafluorobenzoate ester 
• 67593-04-8 (2-Ethoxycarbonylmethyl-4-methoxy-phenyl)-acetic acid ethyl ester 
• 77629-83-5 ethyl 2-bromo-2-(4-methoxyphenyl) acetate 
• 40140-16-7 ethyl (p-methoxyphenyl)oxoacetate 
• 1399983-73-3 ethyl 2-hydroxy-2-(4-methoxyphenyl)-5-methylhex-4-enoate 
• 1399983-79-9 (E)-ethyl 2-hydroxy-2-(4-methoxyphenyl)-5,9-dimethyldeca-4,8-dienoate 
• 75908-61-1 ethyl 4-methoxyphenyl-α-chloroacetate 
• 7074-12-6 3-(4-methoxyphenyl)butan-2-one 
• 123-11-5 4-methoxy-benzaldehyde 

Relevant articles and documents

Exploiting Cofactor Versatility to Convert a FAD-Dependent Baeyer–Villiger Monooxygenase into a Ketoreductase

Cyclohexanone monooxygenases (CHMOs) show very high catalytic specificity for natural Baeyer–Villiger (BV) reactions and promiscuous reduction reactions have not been reported to date. Wild-type CHMO from Acinetobacter sp. NCIMB 9871 was found to possess an innate, promiscuous ability to reduce an aromatic α-keto ester, but with poor yield and stereoselectivity. Structure-guided, site-directed mutagenesis drastically improved the catalytic carbonyl-reduction activity (yield up to 99 %) and stereoselectivity (ee up to 99 %), thereby converting this CHMO into a ketoreductase, which can reduce a range of differently substituted aromatic α-keto esters. The improved, promiscuous reduction activity of the mutant enzyme in comparison to the wild-type enzyme results from a decrease in the distance between the carbonyl moiety of the substrate and the hydrogen atom on N5 of the reduced flavin adenine dinucleotide (FAD) cofactor, as confirmed using docking and molecular dynamics simulations.

Endothelin antagonists benzene oxygen benzene acetic acids and its preparation method and application

The invention provides a phenoxy phenylacetic acid endothelin antagonist shown in a formula (I) or a pharmaceutically acceptable salt thereof, and also provides a preparation method of the benzene oxygen phenylacetic acid endothelin antagonist or the pharmaceutically acceptable salt thereof, and an application thereof in preparation of a medicament for treating cardiovascular and cerebrovascular diseases, tumors, diabetes mellitus, nephrosis, asthma or hyperthyroidism.

Iron-catalyzed hydrogenation for the in situ regeneration of an NAD(P)H model: Biomimetic reduction of α-Keto-/α-iminoesters

Two irons for a smoother finish: An NAD(P)H model was regenerated readily in situ by iron-catalyzed reduction with molecular hydrogen. The subsequent biomimetic reduction of α-keto-/ α-iminoesters proceeded smoothly in the presence of an iron-based Lewis acid (LA) to provide α-hydroxyesters and amino acid esters in good to excellent yields (see scheme; NAD(P) +=nicotinamide adenine dinucleotide (phosphate), TM=transition metal). Copyright