Phosphonic acid, [[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl][(3,4-dihydro-5-methyl-2, 4-dioxo-1(2H)-pyrimidinyl)acetyl]amino]methyl]-, monophenyl ester

Base Information

Chemical Name:Phosphonic acid, [[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl][(3,4-dihydro-5-methyl-2, 4-dioxo-1(2H)-pyrimidinyl)acetyl]amino]methyl]-, monophenyl ester
CAS No.:184159-48-6
Molecular Formula:C₃₇H₃₈N₃O₉P
Molecular Weight:699.697
Hs Code.:

Phosphonic acid,
[[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl][(3,4-dihydro-5-methyl-2,
4-dioxo-1(2H)-pyrimidinyl)acetyl]amino]methyl]-, monophenyl ester

Synonyms:

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Chemical Property of Phosphonic acid, [[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl][(3,4-dihydro-5-methyl-2, 4-dioxo-1(2H)-pyrimidinyl)acetyl]amino]methyl]-, monophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Phosphonic acid, [[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl][(3,4-dihydro-5-methyl-2, 4-dioxo-1(2H)-pyrimidinyl)acetyl]amino]methyl]-, monophenyl ester

There total 7 articles about Phosphonic acid, [[[2-[bis(4-methoxyphenyl)phenylmethoxy]ethyl][(3,4-dihydro-5-methyl-2, 4-dioxo-1(2H)-pyrimidinyl)acetyl]amino]methyl]-, monophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 184159-46-4
({{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid diphenyl ester

: 184159-48-6
({{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid monophenyl ester

Guidance literature:: With water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 0.25h; Yield given;
DOI:10.1016/0040-4039(96)01750-9

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 184159-48-6
({{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid monophenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine

2: hydrazine

3: ethyl acetate / 0.25 h

4: toluene / 2 h / 75 °C

5: N-methyl-morpholine / toluene

6: 75 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / dimethylformamide / 1 h / 75 °C

7: 1,8-diazabicyclo<5.4.0>undec-7-ene, H₂O / acetonitrile / 0.25 h / 20 °C

With 4-methyl-morpholine; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; hydrazine; In pyridine; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/0040-4039(96)01750-9

Reference yield:

: 153765-10-7
2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethanamine

: 184159-48-6
({{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid monophenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: ethyl acetate / 0.25 h

2: toluene / 2 h / 75 °C

3: N-methyl-morpholine / toluene

4: 75 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / dimethylformamide / 1 h / 75 °C

5: 1,8-diazabicyclo<5.4.0>undec-7-ene, H₂O / acetonitrile / 0.25 h / 20 °C

With 4-methyl-morpholine; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/0040-4039(96)01750-9