184159-46-4

Upstream product

• 65-71-4 thymin 
• 184159-45-3 {[{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-(2-bromo-acetyl)-amino]-methyl}-phosphonic acid diphenyl ester 
• 20924-05-4 thymidyl acetic acid 
• 184159-44-2 N-<2-(4,4'-dimethoxytrityl)oxyethyl>aminomethyldiphenyl phosphonate 
• 4712-55-4 diphenyl hydrogen phosphite 
• 153765-10-7 2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethanamine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 184159-43-1 {2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-methylene-amine 
• 184241-26-7 2-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)isoindoline-1,3-dione 

Downstream Products

• 184159-53-3 ({{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid mono-(4-methoxy-1-oxy-pyridin-2-ylmethyl) ester 
• 184159-50-0 ({{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid 4-methoxy-1-oxy-pyridin-2-ylmethyl ester phenyl ester 
• 184159-48-6 ({{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-ethyl}-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid monophenyl ester 

Relevant academic research and scientific papers

Synthesis and binding study of phosphonate analogues of PNAs and their hybrids with PNAs

The preparation of monomers for the synthesis of phosphonate analogues of peptide nucleic acids containing the four natural nucleobases: thymine, cytosine, adenine and guanine, has been accomplished. The monomers obtained were used for the automated online solid phase synthesis of pure phosphono- PNA oligomers as well as chimeras consisting of phosphono-PNA and PNA resudies. The hybridization properties of these oligonucleotide mimics to complementary DNA and RNA fragments were studied.

An approach towards the synthesis of oligomers containing a N-2-hydroxyethyl-aminomethylphosphonate backbone: A novel PNA analogues

A convenient route to the preparation of 4-methoxy-1-oxido-pyridine-2-methyl N-2-(4,4'-dimethoxytrityloxy)ethyl-N-thymin-1-yl aminomethylphosphonate (1a T*) and the corresponding N4-benzoylcytosin-1-yl derivative 1b (C*) is reported. The PPNA monomers proved to be suitable building blocks in a solid-support synthesis of the tetradecameric fragment (C*T*T*T*C*T*T*T*T*C*T*C*T*)dT.