N-(4-Hydroxyphenyl)acrylamide

Base Information

• Chemical Name: N-(4-Hydroxyphenyl)acrylamide
• CAS No.: 34443-04-4
• Molecular Formula: C9H9 N O2
• Molecular Weight: 163.176
• Hs Code.: 2924299090
• European Community (EC) Number: 252-026-9
• DSSTox Substance ID: DTXSID00188014
• Nikkaji Number: J66.963F
• Wikidata: Q83059782
• ChEMBL ID: CHEMBL1802303
• Mol file: 34443-04-4.mol

Synonyms:N-(4-Hydroxyphenyl)acrylamide;34443-04-4;N-(4-hydroxyphenyl)prop-2-enamide;4'-Hydroxyacrylanilide;ACRYLANILIDE, 4'-HYDROXY-;2-Propenamide, N-(4-hydroxyphenyl)-;BRN 2638744;N-(4-Hydroxyphenyl)-2-propenamide;EINECS 252-026-9;n-hydroxyphenyl acrylamide;SCHEMBL133445;CHEMBL1802303;DTXSID00188014;N-(4-Hydroxy-phenyl)-acrylamide;MFCD01673905;LS-14650;SY288307;FT-0718553

Chemical Property of N-(4-Hydroxyphenyl)acrylamide

Chemical Property:

• Vapor Pressure: 1.65E-06mmHg at 25°C
• Boiling Point: 385.9°Cat760mmHg
• PKA: 10.03±0.26(Predicted)
• Flash Point: 187.2°C
• PSA: 49.33000
• Density: 1.231g/cm³
• LogP: 1.58970
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 163.063328530
• Heavy Atom Count: 12
• Complexity: 171

Purity/Quality:

99.3% ^*data from raw suppliers

N-(4-HYDROXYPHENYL)ACRYLAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=CC(=O)NC1=CC=C(C=C1)O

Technology Process of N-(4-Hydroxyphenyl)acrylamide

There total 4 articles about N-(4-Hydroxyphenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

acetic acid 4-acryloylamino-phenyl ester → N-(4-hydroxyphenyl)-2-propenamide (34443-04-4)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 0.166667h;

Reference yield:

4-amino-phenol (123-30-8) + acrylic acid (79-10-7) → N-(4-hydroxyphenyl)-2-propenamide (34443-04-4)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1021/jm200256g

Reference yield:

4-amino-phenol (123-30-8) + acryloyl chloride (814-68-6,25189-84-8) → N-(4-hydroxyphenyl)-2-propenamide (34443-04-4)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water;

DOI:10.1021/ac5004135

upstream raw materials:

4-amino-phenol

acrylic acid

acryloyl chloride

Downstream raw materials:

N-(4-Hydroxy-phenyl)-3-(4-pyridin-2-yl-piperazin-1-yl)-propionamide

N-(4-hydroxy-phenyl)-3-(4-phenyl-piperazin-1-yl)-propionamide

C₃₄H₄₇N₃O₁₀

C₃₀H₃₉N₃O₁₀