3-[3-[1-(N-Isopropyl-N-phenylcarbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]ureido]benzoic acid

Base Information

• Chemical Name: 3-[3-[1-(N-Isopropyl-N-phenylcarbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]ureido]benzoic acid
• CAS No.: 184945-01-5
• Molecular Formula: C34H31N5O6
• Mol file: 184945-01-5.mol

Synonyms:

Chemical Property of 3-[3-[1-(N-Isopropyl-N-phenylcarbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]ureido]benzoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[3-[1-(N-Isopropyl-N-phenylcarbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]ureido]benzoic acid

There total 7 articles about 3-[3-[1-(N-Isopropyl-N-phenylcarbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]ureido]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

→ 3-{3-[1-(Isopropyl-phenyl-carbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-3-yl]-ureido} benzoic acid (184945-01-5)

Guidance literature:

Reference yield:

3-{3-[1-(Isopropyl-phenyl-carbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-3-yl]-ureido}benzoic acid ethyl ester (161455-82-9) → 3-{3-[1-(Isopropyl-phenyl-carbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-3-yl]-ureido} benzoic acid (184945-01-5)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; methanol; for 2.5h; Heating;

DOI:10.1021/jm9601664

Reference yield:

2-bromo-N-isopropyl-N-phenyl-acetamide (161455-97-6) → 3-{3-[1-(Isopropyl-phenyl-carbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-3-yl]-ureido} benzoic acid (184945-01-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 10.0 g / K₂CO₃ / dimethylformamide

2: 7.5 g / tetrahydrofuran / 4 h / Ambient temperature

3: 6.3 g / Zn, glacial AcOH / 1 h / Ambient temperature

4: 312 mg / a) CH₂Cl₂, RT, 30 min, b) CH₃CN, reflux, 1 h

5: 225 mg / 5percent aq. K₂CO₃ / methanol; tetrahydrofuran / 2.5 h / Heating

With potassium carbonate; acetic acid; zinc; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm9601664

upstream raw materials:

3-{3-[1-(Isopropyl-phenyl-carbamoylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine-3-yl]-ureido}benzoic acid ethyl ester

2-bromo-N-isopropyl-N-phenyl-acetamide

N-isopropyl-N-phenyl-2-(2-phenylamino-phenylamino)-acetamide

2-(3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenylacetamide