1-[(Isopropylphenylcarbamoyl)methyl]-3-amino-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione

Base Information

Chemical Name:1-[(Isopropylphenylcarbamoyl)methyl]-3-amino-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
CAS No.:184944-86-3
Molecular Formula:C₂₆H₂₆N₄O₃
Molecular Weight:442.517
Hs Code.:
DSSTox Substance ID:DTXSID60892403
Nikkaji Number:J747.971I
ChEMBL ID:CHEMBL3430923

Synonyms:2-(3-Amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo [b] [1, 4] diazepine-1-yl)-N-isopropyl-N-phenyl acetamide;2-{3-Amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo [b] [1, 4] diazepine-1-yl)-N-isopropyl-N-phenyl acetamide;SCHEMBL7550570;CHEMBL3430923;DTXSID60892403;SNGMAIJHCWVIEO-UHFFFAOYSA-N;TCMDC-143071;(R,S)-3-AMINO-2,3,4,5-TETRAHYDRO-N-(1-METHYLETHYL)-2,4-DIOXO-N,5-DIPHENYL-1H-1,5-BENZODIAZEPINE-1-ACETAMIDE;1-[(Isopropylphenylcarbamoyl)methyl]-3-amino-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione;184944-86-3;2-(3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenyl-acetamide;2-(3-Amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo-[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenylacetamide;2-(3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenyl-acetamide

Suppliers and Price of 1-[(Isopropylphenylcarbamoyl)methyl]-3-amino-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[(Isopropylphenylcarbamoyl)methyl]-3-amino-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:442.20049070
Heavy Atom Count:33
Complexity:714

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)N(C1=CC=CC=C1)C(=O)CN2C3=CC=CC=C3N(C(=O)C(C2=O)N)C4=CC=CC=C4

Technology Process of 1-[(Isopropylphenylcarbamoyl)methyl]-3-amino-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione

There total 6 articles about 1-[(Isopropylphenylcarbamoyl)methyl]-3-amino-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 534-85-0
N-phenyl-1,2-benzenediamine

: 184944-86-3
2-(3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 10.0 g / K₂CO₃ / dimethylformamide

2: 7.5 g / tetrahydrofuran / 4 h / Ambient temperature

3: 6.3 g / Zn, glacial AcOH / 1 h / Ambient temperature

With potassium carbonate; acetic acid; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm9601664

Reference yield:

: 161455-97-6
2-bromo-N-isopropyl-N-phenyl-acetamide

: 184944-86-3
2-(3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 10.0 g / K₂CO₃ / dimethylformamide

2: 7.5 g / tetrahydrofuran / 4 h / Ambient temperature

3: 6.3 g / Zn, glacial AcOH / 1 h / Ambient temperature

With potassium carbonate; acetic acid; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm9601664

Reference yield:

: 161455-90-9
N-isopropyl-N-phenyl-2-(2-phenylamino-phenylamino)-acetamide

: 184944-86-3
2-(3-amino-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydrobenzo[b][1,4]diazepin-1-yl)-N-isopropyl-N-phenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 7.5 g / tetrahydrofuran / 4 h / Ambient temperature

2: 6.3 g / Zn, glacial AcOH / 1 h / Ambient temperature

With acetic acid; zinc; In tetrahydrofuran;
DOI:10.1021/jm9601664