3-BENZYLOXY-2-CHLORO-6-IODOPYRIDINE

Base Information

• Chemical Name: 3-BENZYLOXY-2-CHLORO-6-IODOPYRIDINE
• CAS No.: 185221-60-7
• Molecular Formula: C₁₂H₉ClINO
• Molecular Weight: 345.567
• Mol file: 185221-60-7.mol

Synonyms:

Chemical Property of 3-BENZYLOXY-2-CHLORO-6-IODOPYRIDINE

Chemical Property:

• PSA: 22.12000
• LogP: 3.91860

Purity/Quality:

97% ^*data from raw suppliers

3-Benzyloxy-2-chloro-6-iodo-pyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BENZYLOXY-2-CHLORO-6-IODOPYRIDINE

There total 4 articles about 3-BENZYLOXY-2-CHLORO-6-IODOPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

benzyl bromide (100-39-0) + 2-chloro-3-hydroxy-6-iodo-pyridine (185220-68-2) → 3-(benzyloxy)-2-chloro-6-iodopyridine (185221-60-7)

Guidance literature:

2-chloro-3-hydroxy-6-iodo-pyridine; With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

benzyl bromide; In dimethyl sulfoxide; for 2h;

DOI:10.1021/ol501967c

Reference yield:

benzyl bromide (100-39-0) + 2-chloro-3-hydroxy-6-iodo-pyridine (185220-68-2) → 3-(benzyloxy)-2-chloro-6-iodopyridine (185221-60-7)

Guidance literature:

In methanol; ethyl acetate;

Reference yield:

benzyl bromide (100-39-0) + potassium carbonate (584-08-7) + 2-chloro-3-hydroxy-6-iodo-pyridine (185220-68-2) → 3-(benzyloxy)-2-chloro-6-iodopyridine (185221-60-7)

Guidance literature:

In methanol; ethyl acetate;

upstream raw materials:

benzyl bromide

potassium carbonate

2-chloro-3-hydroxy-6-iodo-pyridine

2-chloro-3-hydroxypyridine

Refernces

• 1、 -. "TRICYCLIC IMIDAZOLE COMPOUNDS AS INHIBITORS OF TRYPTOPHAN HYDROXYLASE". Page/Page column 103. . Retrieved 2015/06/08.
• 2、 Gonda, Zsombor,Kovacs, Szabolcs,Weber, Csaba,Gati, Tamas,Meszaros, Attila,Kotschy, Andras,Novak, Zoltan. "Efficient copper-catalyzed trifluoromethylation of aromatic and heteroaromatic iodides: The beneficial anchoring effect of borates". supporting information. p. 4268 - 4271. Retrieved 2014/09/30.