Chemical Property of 2-Chloro-3-hydroxypyridine
Chemical Property:
- Appearance/Colour:light beige powder
- Vapor Pressure:0.000225mmHg at 25°C
- Melting Point:168-172 °C
- Refractive Index:1.583
- Boiling Point:316.2 °C at 760 mmHg
- PKA:4.32±0.10(Predicted)
- Flash Point:145 °C
- PSA：33.12000
- Density:1.392 g/cm3
- LogP:1.44060
- Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
- XLogP3:1.1
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:0
- Exact Mass:128.9981414
- Heavy Atom Count:8
- Complexity:78.8
- Purity/Quality:
-
99% *data from raw suppliers
2-Chloro-3-hydroxypyridine *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn,
Xi
- Hazard Codes:Xi,Xn
- Statements:
36/37/38-20/21/22
- Safety Statements:
26-37/39-24/25-36
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CC(=C(N=C1)Cl)O
-
Uses
2-Chloro-3-hydroxypyridine has been used in the preparation of 3-hydroxypyridine-2( 1 H)-selone. It has also been used in the synthesis of all four possible benzo[4,5]furopyridine tricyclic heterocycles: benzo[4,5]furo[2,3-b]pyridine, benzo[4,5]furo[2,3-c]pyridine, benzo[4,5]furo[3,2-c]pyridine, and benzo[4,5]furo[3,2-b]pyridine. the synthesis involves α and γ-activation of chloropyridines, as well as palladium-mediated reactions.
