6,7-Dimethoxy-4-phenylcoumarin

Base Information

• Chemical Name: 6,7-Dimethoxy-4-phenylcoumarin
• CAS No.: 1857-05-2
• Molecular Formula: C17H14O4
• Molecular Weight: 282.296
• Hs Code.: 2932209090
• Mol file: 1857-05-2.mol

Synonyms:6,7-dimethoxy-4-phenyl-coumarin;6,7-dimethoxy-4-phenyl-chromen-2-one;6,7-Dimethoxy-4-phenyl-cumarin;4 phenyl-6,7 dimeo coumarin;6,7-Dimethoxy-4-phenylcumarin;methyl dalbergin;

Chemical Property of 6,7-Dimethoxy-4-phenylcoumarin

Chemical Property:

• PSA: 48.67000
• LogP: 3.47720

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6,7-Dimethoxy-4-phenylcoumarin

There total 7 articles about 6,7-Dimethoxy-4-phenylcoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-Hydroxy-7-methoxy-4-phenyl-coumarin (482-83-7) + methyl iodide (74-88-4) → 6,7-dimethoxy-4-phenyl-2H-chromen-2-one (1857-05-2)

Guidance literature:

With potassium carbonate; In acetone; at 40 ℃; for 4h;

DOI:10.1016/j.bmcl.2017.02.062

Reference yield: 84.0%

Scoparone (120-08-1) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 6,7-dimethoxy-4-phenyl-2H-chromen-2-one (1857-05-2)

Guidance literature:

With palladium(II) trimethylacetate; silver pivalate; cesium pivalate; at 100 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1039/c2cc34551j

Reference yield: 75.0%

2-hydroxy-4,5-dimethoxybenzophenone (36896-99-8) + malonic acid dimethyl ester (108-59-8) → 6,7-dimethoxy-4-phenyl-2H-chromen-2-one (1857-05-2)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 180 ℃; for 0.116667h; Microwave irradiation; Neat (no solvent);

DOI:10.1002/ejoc.201000051

upstream raw materials:

nordalbergin

dimethyl sulfate

2-hydroxy-4,5-dimethoxybenzophenone

acetic anhydride

Downstream raw materials:

3-phenyl-3-(2,4,5-trimethoxy-phenyl)-acrylic acid

6-Hydroxy-7-methoxy-4-phenyl-coumarin

3-bromo-6,7-dimethoxy-4-phenyl-coumarin

5,6-dimethoxy-3-phenylbenzofuran