(3R)-4-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-3-hydroxy-butanoic Acid Ethyl Ester

Base Information

• Chemical Name: (3R)-4-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-3-hydroxy-butanoic Acid Ethyl Ester
• CAS No.: 188635-30-5
• Molecular Formula: C12H26O4Si
• Molecular Weight: 262.41800
• Mol file: 188635-30-5.mol

Synonyms:(3R)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-butanoic Acid Ethyl Ester;

Chemical Property of (3R)-4-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-3-hydroxy-butanoic Acid Ethyl Ester

Chemical Property:

• PSA: 55.76000
• LogP: 2.32230
• Solubility.: Dichloromethane, Ethyl Acetate

Purity/Quality:

95% ^*data from raw suppliers

(3R)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-butanoicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (3R)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-butanoic Acid Ethyl Ester is used in the synthetic preparation of 35-deoxy amphotericin B Me ester towards strategies for molecular editing.

Technology Process of (3R)-4-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-3-hydroxy-butanoic Acid Ethyl Ester

There total 2 articles about (3R)-4-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-3-hydroxy-butanoic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.5%

(+)-(R)-ethyl 3,4-dihydroxybutanoate (112635-76-4) + tert-butyldimethylsilyl chloride (18162-48-6) → ethyl 4-[(tert-butyldimethylsilyl)oxy]-(3R)-2-hydroxybutanoate (188635-30-5)

Guidance literature:

With 1H-imidazole; In tetrahydrofuran; at 0 ℃; for 3h;

DOI:10.1016/S0957-4166(96)00517-4

Reference yield:

diethyl (R)-malate (7554-28-1) → ethyl 4-[(tert-butyldimethylsilyl)oxy]-(3R)-2-hydroxybutanoate (188635-30-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) BH₃*Me₂S, 2.) NaBH₄ / 1.) THF, 20 deg C, 45 min, 2.) THF, RT, 1 h

2: 83.5 percent / imidazole / tetrahydrofuran / 3 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; dimethylsulfide borane complex; In tetrahydrofuran;

DOI:10.1016/S0957-4166(96)00517-4

upstream raw materials:

(+)-(R)-ethyl 3,4-dihydroxybutanoate

tert-butyldimethylsilyl chloride

diethyl (R)-malate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 188635-30-5 (3R)-4-[[(1,1-DiMethylethyl)diMethylsilyl]oxy]-3-hydroxy-butanoic Acid Ethyl Ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send