2H-Pyran-2-carboxylic acid, 3,4-dihydro-, phenylmethyl ester

Base Information

• Chemical Name: 2H-Pyran-2-carboxylic acid, 3,4-dihydro-, phenylmethyl ester
• CAS No.: 188676-40-6
• Molecular Formula: C13H14O3
• Molecular Weight: 218.252
• DSSTox Substance ID: DTXSID80455438

Synonyms:2H-Pyran-2-carboxylic acid, 3,4-dihydro-, phenylmethyl ester;188676-40-6;DTXSID80455438

Chemical Property of 2H-Pyran-2-carboxylic acid, 3,4-dihydro-, phenylmethyl ester

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 218.094294304
• Heavy Atom Count: 16
• Complexity: 254

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC(OC=C1)C(=O)OCC2=CC=CC=C2

Technology Process of 2H-Pyran-2-carboxylic acid, 3,4-dihydro-, phenylmethyl ester

There total 1 articles about 2H-Pyran-2-carboxylic acid, 3,4-dihydro-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3,4-dihydro-2H-pyran-2-carboxylic acid sodium salt (16698-52-5) + benzyl bromide (100-39-0) → 3,4-Dihydro-2H-pyran-2-carboxylic acid benzyl ester (188676-40-6)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 25 ℃; for 24h;

DOI:10.1039/a707934f

Reference yield: 85.0%

3,4-Dihydro-2H-pyran-2-carboxylic acid benzyl ester (188676-40-6) + Fmoc-Thr(t-Bu)-ol (189337-28-8,438239-28-2) → 6-[(2R,3R)-3-tert-Butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butoxy]-tetrahydro-pyran-2-carboxylic acid benzyl ester (205590-54-1)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; for 12h;

DOI:10.1039/a707934f

Reference yield: 68.0%

3,4-Dihydro-2H-pyran-2-carboxylic acid benzyl ester (188676-40-6) + (-)-N13-Desmethyl-C12-desisopropyl-C12-phenylmethylindolactam V (252292-65-2) → 6-((10S,13S)-10-Benzyl-11-oxo-3,9,12-triaza-tricyclo[6.6.1.04,15]pentadeca-1,4,6,8(15)-tetraen-13-ylmethoxy)-tetrahydro-pyran-2-carboxylic acid benzyl ester (319922-14-0)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 40 ℃; for 1h;

DOI:10.1002/1521-3765(20001103)6:21<3943::AID-CHEM3943<3.3.CO;2-K

upstream raw materials:

3,4-dihydro-2H-pyran-2-carboxylic acid sodium salt

benzyl bromide

Downstream raw materials:

6-[(2R,3R)-3-tert-Butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butoxy]-tetrahydro-pyran-2-carboxylic acid benzyl ester

6-((10S,13S)-10-Isopropyl-11-oxo-3,9,12-triaza-tricyclo[6.6.1.0^4,15]pentadeca-1,4,6,8⁽¹⁵⁾-tetraen-13-ylmethoxy)-tetrahydro-pyran-2-carboxylic acid benzyl ester

6-((10S,13S)-10-Methyl-11-oxo-3,9,12-triaza-tricyclo[6.6.1.0^4,15]pentadeca-1,4,6,8⁽¹⁵⁾-tetraen-13-ylmethoxy)-tetrahydro-pyran-2-carboxylic acid benzyl ester

6-((10S,13S)-10-Benzyl-11-oxo-3,9,12-triaza-tricyclo[6.6.1.0^4,15]pentadeca-1,4,6,8⁽¹⁵⁾-tetraen-13-ylmethoxy)-tetrahydro-pyran-2-carboxylic acid benzyl ester

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