5,7-Dioxa-8-aza-2-silatetradecan-14-oic acid, 13-[[[(4S)-4,5-dihydro-2-(2-hydroxyphenyl)-4-oxazolyl]carbonyl]amino]-2 ,2-dimethyl-8-(1-oxohexadecyl)-, (13S)-

Base Information

Chemical Name:5,7-Dioxa-8-aza-2-silatetradecan-14-oic acid, 13-[[[(4S)-4,5-dihydro-2-(2-hydroxyphenyl)-4-oxazolyl]carbonyl]amino]-2 ,2-dimethyl-8-(1-oxohexadecyl)-, (13S)-
CAS No.:188743-88-6
Molecular Formula:C38H65N3O8Si
Molecular Weight:720.035
Hs Code.:

5,7-Dioxa-8-aza-2-silatetradecan-14-oic acid,
13-[[[(4S)-4,5-dihydro-2-(2-hydroxyphenyl)-4-oxazolyl]carbonyl]amino]-2
,2-dimethyl-8-(1-oxohexadecyl)-, (13S)-

Synonyms:

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Chemical Property of 5,7-Dioxa-8-aza-2-silatetradecan-14-oic acid, 13-[[[(4S)-4,5-dihydro-2-(2-hydroxyphenyl)-4-oxazolyl]carbonyl]amino]-2 ,2-dimethyl-8-(1-oxohexadecyl)-, (13S)-

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Technology Process of 5,7-Dioxa-8-aza-2-silatetradecan-14-oic acid, 13-[[[(4S)-4,5-dihydro-2-(2-hydroxyphenyl)-4-oxazolyl]carbonyl]amino]-2 ,2-dimethyl-8-(1-oxohexadecyl)-, (13S)-

There total 13 articles about 5,7-Dioxa-8-aza-2-silatetradecan-14-oic acid, 13-[[[(4S)-4,5-dihydro-2-(2-hydroxyphenyl)-4-oxazolyl]carbonyl]amino]-2 ,2-dimethyl-8-(1-oxohexadecyl)-, (13S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 157505-72-1
(S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid methyl ester

: 188743-88-6
(S)-6-[Hexadecanoyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: NaHCO₃ / CH₂Cl₂ / 14 h / Ambient temperature

2: 162 mg / Pr₂NEt, DMAP / toluene / 65 °C

3: H₂ / 10percent Pd-C / methanol / 3 h / 760 Torr

4: 91 percent / EDC-HCl, HOAt, DMAP / dimethylformamide / 3 h / Ambient temperature

5: LiOH

With dmap; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; dipropylethylamine; hydrogen; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo980063o

Reference yield:

: 171287-53-9
(S)-2-Benzyloxycarbonylamino-6-(hexadecanoyl-hydroxy-amino)-hexanoic acid methyl ester

: 188743-88-6
(S)-6-[Hexadecanoyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 162 mg / Pr₂NEt, DMAP / toluene / 65 °C

2: H₂ / 10percent Pd-C / methanol / 3 h / 760 Torr

3: 91 percent / EDC-HCl, HOAt, DMAP / dimethylformamide / 3 h / Ambient temperature

4: LiOH

With dmap; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; dipropylethylamine; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo980063o

Reference yield:

: 188743-80-8
(S)-2-Benzyloxycarbonylamino-6-[hexadecanoyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-hexanoic acid methyl ester

: 188743-88-6
(S)-6-[Hexadecanoyl-(2-trimethylsilanyl-ethoxymethoxy)-amino]-2-{[(S)-2-(2-hydroxy-phenyl)-4,5-dihydro-oxazole-4-carbonyl]-amino}-hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd-C / methanol / 3 h / 760 Torr

2: 91 percent / EDC-HCl, HOAt, DMAP / dimethylformamide / 3 h / Ambient temperature

3: LiOH

With dmap; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jo980063o