(S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid methyl ester

Base Information

• Chemical Name: (S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid methyl ester
• CAS No.: 157505-72-1
• Molecular Formula: C₁₅H₂₂N₂O₅
• Molecular Weight: 310.35
• Mol file: 157505-72-1.mol

Synonyms:(S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid methyl ester

Chemical Property of (S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid methyl ester

There total 9 articles about (S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

C18H26N2O5 (157505-71-0) → (S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid methyl ester (157505-72-1)

Guidance literature:

With hydrogenchloride; for 0.333333h; Ambient temperature;

DOI:10.1021/jo00096a030

Reference yield:

methanol (67-56-1) + (S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid (171287-56-2) → (S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid methyl ester (157505-72-1)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 16h;

DOI:10.1039/b703116e

Reference yield:

N-(benzyloxycarbonyl)lysine methyl ester hydrochloride (26348-68-5) → (S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid methyl ester (157505-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) aq. NaHCO₃, 2.) dimethyldioxirane / 2.) -78 deg C, 10 min

2: 41 percent / aq. HCl / 0.33 h / Ambient temperature

With hydrogenchloride; 3,3-dimethyldioxirane; sodium hydrogencarbonate;

DOI:10.1021/jo00096a030

upstream raw materials:

C₁₈H₂₆N₂O₅

methanol

(S)-2-Benzyloxycarbonylamino-6-hydroxyamino-hexanoic acid

C₂₁H₂₄N₂O₅

Downstream raw materials:

(S)-2-Benzyloxycarbonylamino-6-(hexadecanoyl-hydroxy-amino)-hexanoic acid methyl ester

C₄₇H₈₂N₂O₇

C₄₆H₆₅N₃O₈

C₄₅H₆₃N₃O₈