Benzeneethanol, a-(3-hydroxy-4-methoxyphenyl)-3,4,5-trimethoxy-

Base Information

• Chemical Name: Benzeneethanol, a-(3-hydroxy-4-methoxyphenyl)-3,4,5-trimethoxy-
• CAS No.: 113931-91-2
• Molecular Formula: C18H22 O6
• Molecular Weight: 334.36368
• Mol file: 113931-91-2.mol

Synonyms:(?à)-Isocombretastatin; (?à)-Isocombretastatin A;Isocombretastatin A

Chemical Property of Benzeneethanol, a-(3-hydroxy-4-methoxyphenyl)-3,4,5-trimethoxy-

Chemical Property:

• PSA: 77.38000
• LogP: 2.70270

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneethanol, a-(3-hydroxy-4-methoxyphenyl)-3,4,5-trimethoxy-

There total 5 articles about Benzeneethanol, a-(3-hydroxy-4-methoxyphenyl)-3,4,5-trimethoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-oxo-1-(3''-hydroxy-4''-methoxyphenyl)-2-(3',4'.5'-trimethoxyphenyl)ethane (117048-66-5) → 5-[1-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]-2-methoxyphenol (113931-91-2)

Guidance literature:

With sodium tetrahydroborate; In methanol;

Reference yield: 67.0%

1-(3-(ethoxymethoxy)-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethanol (956699-47-1) → 5-[1-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]-2-methoxyphenol (113931-91-2)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; at 0 ℃;

DOI:10.1016/j.tet.2007.09.010

Reference yield:

1-[4-methoxy-3-(phenylmethoxy)phenyl]-2-(3,4,5-trimethoxyphenyl)-ethanone (56766-92-8) → 5-[1-hydroxy-2-(3,4,5-trimethoxyphenyl)ethyl]-2-methoxyphenol (113931-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / HCOONH₄ / Pd/C / methanol / Heating

2: 90 percent / NaBH₄ / methanol

With sodium tetrahydroborate; ammonium formate; palladium on activated charcoal; In methanol;

upstream raw materials:

3,4,5-trimethoxybenzyl bromide

p-methoxy-m-(tert-butyldimethylsilyloxy)-benzaldehyde

1-oxo-1-(3''-hydroxy-4''-methoxyphenyl)-2-(3',4'.5'-trimethoxyphenyl)ethane

1-(3-(ethoxymethoxy)-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethanol

Downstream raw materials:

1-oxo-1-(3''-hydroxy-4''-methoxyphenyl)-2-(3',4'.5'-trimethoxyphenyl)ethane