2-Hydrazino-4,6-dimethylpyrimidine

Base Information

• Chemical Name: 2-Hydrazino-4,6-dimethylpyrimidine
• CAS No.: 23906-13-0
• Molecular Formula: C6H10N4
• Molecular Weight: 138.172
• Hs Code.: 2933599590
• Mol file: 23906-13-0.mol

Synonyms:2(1H)-Pyrimidinone,4,6-dimethyl-, hydrazone (7CI,9CI);Pyrimidine, 2-hydrazino-4,6-dimethyl-(6CI,8CI);2-Hydrazino-4,6-dimethylpyrimidine;4,6-Dimethyl-2-hydrazinopyrimidine;4,6-Dimethyl-2-pyrimidinylhydrazine;NSC512294;

Chemical Property of 2-Hydrazino-4,6-dimethylpyrimidine

Chemical Property:

• Vapor Pressure: 0.000517mmHg at 25°C
• Melting Point: 165 °C
• Refractive Index: 1.623
• Boiling Point: 312.8 °C at 760 mmHg
• PKA: 6.44±0.70(Predicted)
• Flash Point: 143 °C
• PSA: 63.83000
• Density: 1.2 g/cm³
• LogP: 1.15230
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

(4,6-Dimethyl-pyrimidin-2-yl)-hydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: 2-Hydrazino-4,6-dimethylpyrimidine is a chemical compound with applications in various fields. In the field of pharmaceuticals and medicinal chemistry, it can serve as a valuable intermediate for the synthesis of pyrimidine-based compounds with potential biological activities. Its unique chemical structure allows for the modification of specific positions, enabling the creation of diverse pharmaceutical agents, including antiviral, anticancer, and antibacterial drugs. Its role here is fundamental in advancing drug development and the production of therapeutic agents targeting various medical conditions. Moreover, in the field of analytical chemistry, this compound may find use as a reagent for the detection and quantification of certain analytes through chemical assays. Its reaction with specific substances can lead to the formation of detectable products, aiding in the determination of analyte concentrations. Its significance varies within these fields, but it consistently plays a pivotal role in advancing drug discovery, chemical synthesis, and analytical methods across diverse scientific and industrial applications.

Technology Process of 2-Hydrazino-4,6-dimethylpyrimidine

There total 11 articles about 2-Hydrazino-4,6-dimethylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(4-Chloro-phenyl)-ethanone O-(4,6-dimethyl-pyrimidin-2-yl)-oxime (128381-43-1) → 2-hydrazino-4,6-dimethylpyrimidine (23906-13-0) + 4-chloroacetophenone oxime (1956-39-4)

Guidance literature:

With hydrazine hydrate; In ethanol; for 6h; Heating;

DOI:10.1007/BF00473866

Reference yield: 70.0%

2-chloro-4,6-dimethylpyrimidine (4472-44-0) → 2-hydrazino-4,6-dimethylpyrimidine (23906-13-0)

Guidance literature:

With hydrazine hydrate; In ethanol; at 10 ℃;

DOI:10.1007/s10593-021-02922-6

Reference yield: 70.0%

4,6-dimethyl-2-methylsulfanyl-pyrimidine (14001-64-0) → 2-hydrazino-4,6-dimethylpyrimidine (23906-13-0)

Guidance literature:

With hydrazine hydrate; In ethanol; for 7h; Heating;

upstream raw materials:

2-chloro-4,6-dimethylpyrimidine

4,6-dimethyl-2-methylsulfanyl-pyrimidine

(4,6-dimethyl-pyrimidin-2-yl)-nitro-amine

benzoic acid-[N'-(4,6-dimethyl-pyrimidin-2-yl)-hydrazide]

Downstream raw materials:

5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine

formic acid-[N'-(4,6-dimethyl-pyrimidin-2-yl)-hydrazide]

4,6,4',6'-tetramethyl-2,2'-diazane-1,2-diyl-bis-pyrimidine

1-(4,6-dimethyl-pyrimidin-2-yl)-semicarbazide

Refernces

• 1、 Ostrovskii, Vladimir А.,Danagulyan, Gevorg G.,Nesterova, Olga M.,Pavlyukova, Yulia N.,Tolstyakov, Vladimir V.,Zarubina, Olga S.,Slepukhin, Pavel А.,Esaulkova, Yana L.,Muryleva, Anna А.,Zarubaev, Vladimir V.,Trifonov, Rostislav E.. "Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines". . p. 448 - 454. Retrieved 2021/05/21.
• 2、 Ghosh, Swadesh,Singharoy, Dipti,Dhara, Anamika,Naskar, Jnan Prakash,Bhattacharya, Subhash Chandra. "Nonionic Surfactants as Potential Carriers of a Synthesized Pyrimidine Derivative: Spectroscopic and Quantum Chemical Investigations". . p. 2695 - 2701. Retrieved 2018/06/27.