CarbaMic acid, [(2R)-2-aMino-2-phenylethyl]-, 1,1-diMethylethyl ester

Base Information

Chemical Name:CarbaMic acid, [(2R)-2-aMino-2-phenylethyl]-, 1,1-diMethylethyl ester
CAS No.:188875-37-8
Molecular Formula:C13H20N2O2
Molecular Weight:236.314
Hs Code.:2924299090
Mol file:188875-37-8.mol

Synonyms:

Suppliers and Price of CarbaMic acid, [(2R)-2-aMino-2-phenylethyl]-, 1,1-diMethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

J&W Pharmlab
(R)-(2-Amino-2-phenyl-ethyl)-carbamicacidtert-butylester 97%
5g
$ 1192.00

J&W Pharmlab
(R)-(2-Amino-2-phenyl-ethyl)-carbamicacidtert-butylester 97%
100mg
$ 125.00

J&W Pharmlab
(R)-(2-Amino-2-phenyl-ethyl)-carbamicacidtert-butylester 97%
50mg
$ 110.00

J&W Pharmlab
(R)-(2-Amino-2-phenyl-ethyl)-carbamicacidtert-butylester 97%
250mg
$ 149.00

J&W Pharmlab
(R)-(2-Amino-2-phenyl-ethyl)-carbamicacidtert-butylester 97%
500mg
$ 198.00

J&W Pharmlab
(R)-(2-Amino-2-phenyl-ethyl)-carbamicacidtert-butylester 97%
1g
$ 298.00

Crysdot
(R)-tert-Butyl(2-amino-2-phenylethyl)carbamate 97%
1g
$ 282.00

Crysdot
(R)-tert-Butyl(2-amino-2-phenylethyl)carbamate 97%
5g
$ 1129.00

Chemenu
(R)-N2-Boc-1-phenylethylenediamine 95+%
5g
$ 1066.00

Chemenu
(R)-N2-Boc-1-phenylethylenediamine 95+%
1g
$ 267.00

Total 14 raw suppliers

Chemical Property of CarbaMic acid, [(2R)-2-aMino-2-phenylethyl]-, 1,1-diMethylethyl ester

Chemical Property:

PSA：64.35000
LogP:3.30230
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

(R)-(2-Amino-2-phenyl-ethyl)-carbamicacidtert-butylester 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of CarbaMic acid, [(2R)-2-aMino-2-phenylethyl]-, 1,1-diMethylethyl ester

There total 6 articles about CarbaMic acid, [(2R)-2-aMino-2-phenylethyl]-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: (R)-tert-butyl 2-(2-methoxy-5-methylphenylamino)-2-phenylethylcarbamate

: 188875-37-8
((R)-2-Amino-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: With ammonium cerium (IV) nitrate; In methanol; at -78 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acs.orglett.9b02280

Reference yield:

: 100-52-7
benzaldehyde

: 188875-37-8
((R)-2-Amino-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 3 h / 20 °C / Inert atmosphere

2: C₂₈H₃₂BNO₂*CHF₃O₃S / toluene / 12 h / -40 °C / Inert atmosphere

3: nickel(II) chloride hexahydrate; sodium tetrahydroborate; methanol / 2 h / -78 °C

4: potassium carbonate / acetone / 20 °C / Inert atmosphere

5: ammonium cerium (IV) nitrate / methanol / 3 h / -78 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; ammonium cerium (IV) nitrate; nickel(II) chloride hexahydrate; C₂₈H₃₂BNO₂*CHF₃O₃S; potassium carbonate; In methanol; ethanol; acetone; toluene; 2: |Strecker Aminoacid Synthesis;
DOI:10.1021/acs.orglett.9b02280

Reference yield:

: 19430-24-1
4-methyl-2-[(phenylmethylene)amino]phenol

: 188875-37-8
((R)-2-Amino-2-phenyl-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: (S)-tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazoborolidine / toluene / 16 h / -40 °C / Inert atmosphere

2: nickel(II) chloride hexahydrate; sodium tetrahydroborate; methanol / 2 h / -78 °C

3: potassium carbonate / acetone / 20 °C / Inert atmosphere

4: ammonium cerium (IV) nitrate / methanol / 3 h / -78 °C / Inert atmosphere

With methanol; sodium tetrahydroborate; ammonium cerium (IV) nitrate; nickel(II) chloride hexahydrate; potassium carbonate; (S)-tetrahydro-1,3,3-triphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazoborolidine; In methanol; acetone; toluene; 1: |Strecker Aminoacid Synthesis;
DOI:10.1021/acs.orglett.9b02280