2-Azabicyclo[3.1.0]hexane, 1-methyl-2-phenyl-

Base Information

Chemical Name:2-Azabicyclo[3.1.0]hexane, 1-methyl-2-phenyl-
CAS No.:188969-81-5
Molecular Formula:C₁₂H₁₅N
Molecular Weight:173.258
Hs Code.:

Synonyms:

Suppliers and Price of 2-Azabicyclo[3.1.0]hexane, 1-methyl-2-phenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-Azabicyclo[3.1.0]hexane, 1-methyl-2-phenyl-

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Azabicyclo[3.1.0]hexane, 1-methyl-2-phenyl-

There total 3 articles about 2-Azabicyclo[3.1.0]hexane, 1-methyl-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135579-06-5
N-(2-bromophenyl)-N-but-3-enylacetamide

: 188969-81-5
4-phenyl-5-methyl-4-azabicyclo[3.1.0]hexane

: 1453542-15-8
4-(2-bromophenyl)-5-methyl-4-azabicyclo[3.1.0]hexane

Guidance literature:: N-(2-bromophenyl)-N-but-3-enylacetamide; With titanium(IV) isopropylate; cyclopentylmagnesium chloride; lithium chloride; In tetrahydrofuran; diethyl ether; at 0 - 25 ℃; for 1.23333h; Inert atmosphere;

With acetaldehyde; In tetrahydrofuran; diethyl ether; at 0 ℃; for 1h; Inert atmosphere;

With ammonium hydroxide; In tetrahydrofuran; diethyl ether; for 1h; Inert atmosphere;
DOI:10.1002/chem.201300871

Reference yield:

: 615-36-1
2-bromoaniline

: 188969-81-5
4-phenyl-5-methyl-4-azabicyclo[3.1.0]hexane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 0.5 h / 80 °C

2.1: potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / toluene / 10 h / 80 °C / Inert atmosphere

3.1: titanium(IV) isopropylate; cyclopentylmagnesium chloride; lithium chloride / tetrahydrofuran; diethyl ether / 1.23 h / 0 - 25 °C / Inert atmosphere

3.2: 1 h / 0 °C / Inert atmosphere

3.3: 1 h / Inert atmosphere

With titanium(IV) isopropylate; tetra(n-butyl)ammonium hydrogensulfate; cyclopentylmagnesium chloride; lithium chloride; potassium hydroxide; In tetrahydrofuran; diethyl ether; toluene; 3.1: |Kulinkovich-De Meijere Reaction;
DOI:10.1002/chem.201300871

Reference yield:

: 614-76-6
N-acetyl-2-bromoaniline

: 188969-81-5
4-phenyl-5-methyl-4-azabicyclo[3.1.0]hexane

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / toluene / 10 h / 80 °C / Inert atmosphere

2.1: titanium(IV) isopropylate; cyclopentylmagnesium chloride; lithium chloride / tetrahydrofuran; diethyl ether / 1.23 h / 0 - 25 °C / Inert atmosphere

2.2: 1 h / 0 °C / Inert atmosphere

2.3: 1 h / Inert atmosphere

With titanium(IV) isopropylate; tetra(n-butyl)ammonium hydrogensulfate; cyclopentylmagnesium chloride; lithium chloride; potassium hydroxide; In tetrahydrofuran; diethyl ether; toluene; 2.1: |Kulinkovich-De Meijere Reaction;
DOI:10.1002/chem.201300871