(R)-Ketorolac

Base Information

Chemical Name:(R)-Ketorolac
CAS No.:66635-93-6
Molecular Formula:C15H13NO3
Molecular Weight:255.273
Hs Code.:
UNII:10A5O25ILE
DSSTox Substance ID:DTXSID801317579
Nikkaji Number:J269.530H
Wikidata:Q27145821
ChEMBL ID:CHEMBL1619630

Synonyms:(R)-Ketorolac;66635-93-6;(+)-Ketorolac;(1R)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;(R)-(+)-ketorolac;Ketorolac, (R)-;CHEBI:76227;UNII-10A5O25ILE;10A5O25ILE;CHEMBL1619630;(R)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, (R)-;r-ketorolac;2mji;R-(+)-Ketorolac;SCHEMBL4103;BIDD:GT0192;(+)-Ketorolac(+)-Ketorolac;HY-B0580B;DTXSID801317579;R-Ketorolac, >=95% (HPLC);BDBM50234661;AKOS030240798;CS-O-01710;MS-23596;CS-0093561;EN300-18567394;Q27145821;1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-, (1R)-

Suppliers and Price of (R)-Ketorolac

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-Ketorolac
100mg
$ 1620.00

TRC
(R)-Ketorolac
50mg
$ 920.00

American Custom Chemicals Corporation
(+)-KETOROLAC 95.00%
5MG
$ 499.91

American Custom Chemicals Corporation
(+)-KETOROLAC 95.00%
2MG
$ 350.00

Total 12 raw suppliers

Chemical Property of (R)-Ketorolac

Chemical Property:

Vapor Pressure:1.52E-10mmHg at 25°C
Melting Point:163-170°C
Boiling Point:493.2°Cat760mmHg
Flash Point:252.1°C
PSA：59.30000
Density:1.33g/cm³
LogP:2.29100
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:255.08954328
Heavy Atom Count:19
Complexity:376

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-Ketorolac ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O
Isomeric SMILES:C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)[C@@H]1C(=O)O
Uses (R)-Ketorolac is the R-enantiomer of Ketorolac. The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.

Technology Process of (R)-Ketorolac

There total 25 articles about (R)-Ketorolac which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₂₅NO₅

: 22204-53-1
(2S)-2-(6-methoxy(2-naphthyl))propanoic acid

: 66635-93-6
R-(+)-ketorolac

: 66635-92-5
S-ketorolac

Guidance literature:: With sulfuric acid; In methanol; Sealed tube; Microwave irradiation;
DOI:10.1039/c7nj02898a

Reference yield:

: C₁₆H₁₅NO

: 66635-93-6
R-(+)-ketorolac

: 66635-92-5
S-ketorolac

Guidance literature:: With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; at 0 ℃; for 4h; Overall yield = 82 percent; Overall yield = 14.4 mg; Inert atmosphere;
DOI:10.1016/j.tetlet.2019.151564

Reference yield:

: ((S)-5-Benzoyl-2,3-dihydro-1H-pyrrolizin-1-yl)-((1R,5S,7S)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone

: 66635-93-6
R-(+)-ketorolac

: 66635-92-5
S-ketorolac

Guidance literature:: With 2-methyl-but-2-ene; tetra(n-butyl)ammonium hydroxide; dihydrogen peroxide; In 1,2-dimethoxyethane; at -10 ℃; for 3h; Title compound not separated from byproducts;
DOI:10.1002/anie.200462048