2-Pyrimidinamine, N-[4-(2-bromoethyl)cyclohexyl]-, trans-

Base Information

Chemical Name:2-Pyrimidinamine, N-[4-(2-bromoethyl)cyclohexyl]-, trans-
CAS No.:189153-09-1
Molecular Formula:C12H18BrN3
Molecular Weight:284.199
Hs Code.:

Synonyms:

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Chemical Property of 2-Pyrimidinamine, N-[4-(2-bromoethyl)cyclohexyl]-, trans-

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Technology Process of 2-Pyrimidinamine, N-[4-(2-bromoethyl)cyclohexyl]-, trans-

There total 5 articles about 2-Pyrimidinamine, N-[4-(2-bromoethyl)cyclohexyl]-, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 189153-08-0
2-[4-(Pyrimidin-2-ylamino)-cyclohexyl]-ethanol

: 189153-09-1
[4-(2-Bromo-ethyl)-cyclohexyl]-pyrimidin-2-yl-amine

Guidance literature:: With PS-triphenylphosphine; carbon tetrabromide; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/jm9707378

Reference yield:

: 5445-26-1
ETHYL 4-NITROPHENYLACETATE

: 189153-09-1
[4-(2-Bromo-ethyl)-cyclohexyl]-pyrimidin-2-yl-amine

Guidance literature:: Multi-step reaction with 5 steps

1: 1139 g / H₂, aq. NaOH / Raney Ni / 62.5 h / 20 - 130 °C / 91380.1 - 129701 Torr

2: HCl / 4 h / Heating

3: 71 percent / Et₃N / ethanol / 18 h / Heating

4: 99 percent / LiAlH₄ / tetrahydrofuran / 0.75 h / 0 - 20 °C

5: 67 percent / polymer-supported PPh₃, CBr₄ / CH₂Cl₂ / 1 h / 0 °C

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; PS-triphenylphosphine; carbon tetrabromide; hydrogen; triethylamine; nickel; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm9707378

Reference yield:

: 1197-54-2
trans-(4-amino-cyclohexyl)-acetic acid

: 189153-09-1
[4-(2-Bromo-ethyl)-cyclohexyl]-pyrimidin-2-yl-amine

Guidance literature:: Multi-step reaction with 4 steps

1: HCl / 4 h / Heating

2: 71 percent / Et₃N / ethanol / 18 h / Heating

3: 99 percent / LiAlH₄ / tetrahydrofuran / 0.75 h / 0 - 20 °C

4: 67 percent / polymer-supported PPh₃, CBr₄ / CH₂Cl₂ / 1 h / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; PS-triphenylphosphine; carbon tetrabromide; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm9707378