(4-Amino-cyclohexyl)-acetic acid

Base Information

• Chemical Name: (4-Amino-cyclohexyl)-acetic acid
• CAS No.: 1197-54-2
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.213
• Hs Code.: 2922499990
• Mol file: 1197-54-2.mol

Synonyms:4-Aminocyclohexaneaceticacid;(4-Aminocyclohexyl)acetic acid;2-(4-Aminocyclohexyl)acetic acid;Acetic acid, trans-4-aminocyclohexyl-;AC1L6WIA;CID300537;AG-D-42889;

Chemical Property of (4-Amino-cyclohexyl)-acetic acid

Chemical Property:

• Vapor Pressure: 0.000249mmHg at 25°C
• Refractive Index: 1.487
• Boiling Point: 301.3 °C at 760 mmHg
• Flash Point: 136 °C
• PSA: 63.32000
• Density: 1.075 g/cm³
• LogP: 1.67890
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(4-Aminocyclohexyl)aceticacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-Amino-cyclohexyl)-acetic acid

There total 4 articles about (4-Amino-cyclohexyl)-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-aminophenylacetic acid (1197-55-3) → trans-(4-amino-cyclohexyl)-acetic acid (1197-54-2)

Guidance literature:

With hydrogen; at 50 - 60 ℃; under 750.075 - 3000.3 Torr; Inert atmosphere;

Reference yield:

ETHYL 4-NITROPHENYLACETATE (5445-26-1) → trans-(4-amino-cyclohexyl)-acetic acid (1197-54-2)

Guidance literature:

With sodium hydroxide; hydrogen; nickel; at 20 - 130 ℃; for 62.5h; under 91380.1 - 129701 Torr;

DOI:10.1021/jm9707378

Reference yield:

4-nitrobenzeneacetic acid (104-03-0) → trans-(4-amino-cyclohexyl)-acetic acid (1197-54-2)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon / 20 - 46 °C / 450.05 Torr / Inert atmosphere

2: hydrogen / 50 - 60 °C / 750.08 - 3000.3 Torr / Inert atmosphere

With hydrogen; palladium 10% on activated carbon;

upstream raw materials:

ETHYL 4-NITROPHENYLACETATE

4-nitrobenzeneacetic acid

4-aminophenylacetic acid

Downstream raw materials:

ethyl 2-((1r,4r)-4-aminocyclohexyl)acetate hydrochloride

Refernces

• 1、 Wustrow, David,Belliotti, Thomas,Glase, Shelly,Kesten, Suzanne Ross,Johnson, Don,Colbry, Norman,Rubin, Ronald,Blackburn, Anthony,Akunne, Hyacinth,Corbin, Ann,Duff Davis,Georgic, Lynn,Whetzel, Steven,Zoski, Kim,Heffner, Thomas,Pugsley, Thomas,Wise, Lawrence. "Aminopyrimidines with high affinity for both serotonin and dopamine receptors". . p. 760 - 771. Retrieved 2007/10/03.