Phosphinic acid, [4-methyl-2-[[(phenylmethyl)amino]carbonyl]pentyl](phenylmethyl)-, methyl ester

Base Information

Chemical Name:Phosphinic acid, [4-methyl-2-[[(phenylmethyl)amino]carbonyl]pentyl](phenylmethyl)-, methyl ester
CAS No.:189163-74-4
Molecular Formula:C₂₂H₃₀NO₃P
Molecular Weight:387.459
Hs Code.:

Synonyms:

Suppliers and Price of Phosphinic acid, [4-methyl-2-[[(phenylmethyl)amino]carbonyl]pentyl](phenylmethyl)-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Phosphinic acid, [4-methyl-2-[[(phenylmethyl)amino]carbonyl]pentyl](phenylmethyl)-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Phosphinic acid, [4-methyl-2-[[(phenylmethyl)amino]carbonyl]pentyl](phenylmethyl)-, methyl ester

There total 7 articles about Phosphinic acid, [4-methyl-2-[[(phenylmethyl)amino]carbonyl]pentyl](phenylmethyl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.9%

: 100-46-9
benzylamine

: 2-(Benzyl-methoxy-phosphinoylmethyl)-4-methyl-pentanoic acid 2,5-dioxo-pyrrolidin-1-yl ester

: 189163-74-4
Benzyl-(2-benzylcarbamoyl-4-methyl-pentyl)-phosphinic acid methyl ester

Guidance literature:: In dichloromethane; for 120h; Ambient temperature;
DOI:10.1021/jo962275w

Reference yield:

: 100-39-0
benzyl bromide

: 189163-74-4
Benzyl-(2-benzylcarbamoyl-4-methyl-pentyl)-phosphinic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / N,O-bis(trimethylsilyl)acetamide / CH₂Cl₂ / 1) rt, 20 h; 2) reflux, 8 h; 3) rt, 18 h

2: toluene; methanol; hexane / 0.5 h / Ambient temperature

3: 100 percent / H₂ / Pd on barium sulfate / methanol / 1.5 h / 2327.2 Torr / Ambient temperature

4: 95.5 percent / 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 19 h / Ambient temperature

5: 87.9 percent / CH₂Cl₂ / 120 h / Ambient temperature

With N,O-bis-(trimethylsilyl)-acetamide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on barium sulfate; In methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo962275w

Reference yield:

: 118053-31-9
benzyl 4-methyl-2-methylenepentanoate

: 189163-74-4
Benzyl-(2-benzylcarbamoyl-4-methyl-pentyl)-phosphinic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / hexamethyldisilazane, NH₄H₂PO₂ / CH₂Cl₂ / 16 h / Ambient temperature

2: 100 percent / N,O-bis(trimethylsilyl)acetamide / CH₂Cl₂ / 1) rt, 20 h; 2) reflux, 8 h; 3) rt, 18 h

3: toluene; methanol; hexane / 0.5 h / Ambient temperature

4: 100 percent / H₂ / Pd on barium sulfate / methanol / 1.5 h / 2327.2 Torr / Ambient temperature

5: 95.5 percent / 1-(3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 19 h / Ambient temperature

6: 87.9 percent / CH₂Cl₂ / 120 h / Ambient temperature

With N,O-bis-(trimethylsilyl)-acetamide; ammonium hypophosphorous acid; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1,1,1,3,3,3-hexamethyl-disilazane; palladium on barium sulfate; In methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo962275w