Silane, (1,1-dimethylethyl)[1-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxy -2,6-dimethylphenyl]methyl]-2-nitroethoxy]dimethyl-

Base Information

• Chemical Name: Silane, (1,1-dimethylethyl)[1-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxy -2,6-dimethylphenyl]methyl]-2-nitroethoxy]dimethyl-
• CAS No.: 189217-88-7
• Molecular Formula: C24H45NO5Si2
• Molecular Weight: 483.796
• Mol file: 189217-88-7.mol

Synonyms:

Chemical Property of Silane, (1,1-dimethylethyl)[1-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxy -2,6-dimethylphenyl]methyl]-2-nitroethoxy]dimethyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Silane, (1,1-dimethylethyl)[1-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxy -2,6-dimethylphenyl]methyl]-2-nitroethoxy]dimethyl-

There total 3 articles about Silane, (1,1-dimethylethyl)[1-[[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-methoxy -2,6-dimethylphenyl]methyl]-2-nitroethoxy]dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.5%

tert-butyldimethylsilyl chloride (18162-48-6) + 1-(3-hydroxy-4-methoxy-2,6-dimethylphenyl)-3-nitro-2-propanol (189217-80-9) → 2-(tert-Butyl-dimethyl-silanyloxy)-4-[2-(tert-butyl-dimethyl-silanyloxy)-3-nitro-propyl]-1-methoxy-3,5-dimethyl-benzene (189217-88-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In benzene; for 0.0166667h;

DOI:10.1248/cpb.45.613

Reference yield:

[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6-dimethyl-phenyl]-acetaldehyde (189217-78-5) → 2-(tert-Butyl-dimethyl-silanyloxy)-4-[2-(tert-butyl-dimethyl-silanyloxy)-3-nitro-propyl]-1-methoxy-3,5-dimethyl-benzene (189217-88-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 60.4 percent / KF, 18-crown-6 / propan-2-ol / 33 h / Ambient temperature

2: 65.5 percent / DBU / benzene / 0.02 h

With potassium fluoride; 18-crown-6 ether; 1,8-diazabicyclo[5.4.0]undec-7-ene; In isopropyl alcohol; benzene;

DOI:10.1248/cpb.45.613

Reference yield:

[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6-dimethyl-phenyl]-acetic acid methyl ester (189217-74-1) → 2-(tert-Butyl-dimethyl-silanyloxy)-4-[2-(tert-butyl-dimethyl-silanyloxy)-3-nitro-propyl]-1-methoxy-3,5-dimethyl-benzene (189217-88-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / diisobutylaluminum hydride / diethyl ether; hexane / 2 h / -78 °C

2: 60.4 percent / KF, 18-crown-6 / propan-2-ol / 33 h / Ambient temperature

3: 65.5 percent / DBU / benzene / 0.02 h

With potassium fluoride; 18-crown-6 ether; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In diethyl ether; hexane; isopropyl alcohol; benzene;

DOI:10.1248/cpb.45.613

upstream raw materials:

tert-butyldimethylsilyl chloride

1-(3-hydroxy-4-methoxy-2,6-dimethylphenyl)-3-nitro-2-propanol

[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6-dimethyl-phenyl]-acetaldehyde

[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6-dimethyl-phenyl]-acetic acid methyl ester

Downstream raw materials:

4-[2-(tert-Butyl-dimethyl-silanyloxy)-3-nitro-propyl]-3,5-dimethyl-[1,2]benzoquinone

3-[2-(tert-Butyl-dimethyl-silanyloxy)-3-nitro-propyl]-6-methoxy-2,4-dimethyl-phenol