[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6-dimethyl-phenyl]-acetaldehyde

Base Information

• Chemical Name: [3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6-dimethyl-phenyl]-acetaldehyde
• CAS No.: 189217-78-5
• Molecular Formula: C₁₇H₂₈O₃Si
• Molecular Weight: 308.493
• Mol file: 189217-78-5.mol

Synonyms:[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6-dimethyl-phenyl]-acetaldehyde

Chemical Property of [3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6-dimethyl-phenyl]-acetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6-dimethyl-phenyl]-acetaldehyde

There total 3 articles about [3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6-dimethyl-phenyl]-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6-dimethyl-phenyl]-acetic acid methyl ester (189217-74-1) → [3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6-dimethyl-phenyl]-acetaldehyde (189217-78-5)

Guidance literature:

With diisobutylaluminium hydride; In diethyl ether; hexane; at -78 ℃; for 2h;

DOI:10.1248/cpb.45.613

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → [3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6-dimethyl-phenyl]-acetaldehyde (189217-78-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90.1 percent / DBU / benzene / 0.02 h

2: 94 percent / diisobutylaluminum hydride / diethyl ether; hexane / 2 h / -78 °C

With diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In diethyl ether; hexane; benzene;

DOI:10.1248/cpb.45.613

Reference yield:

(3-Hydroxy-4-methoxy-2,6-dimethyl-phenyl)-acetic acid methyl ester → [3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6-dimethyl-phenyl]-acetaldehyde (189217-78-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90.1 percent / DBU / benzene / 0.02 h

2: 94 percent / diisobutylaluminum hydride / diethyl ether; hexane / 2 h / -78 °C

With diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In diethyl ether; hexane; benzene;

DOI:10.1248/cpb.45.613

upstream raw materials:

[3-(tert-Butyl-dimethyl-silanyloxy)-4-methoxy-2,6-dimethyl-phenyl]-acetic acid methyl ester

tert-butyldimethylsilyl chloride

Downstream raw materials:

4-[2-(tert-Butyl-dimethyl-silanyloxy)-3-nitro-propyl]-3,5-dimethyl-[1,2]benzoquinone

3-[2-(tert-Butyl-dimethyl-silanyloxy)-3-nitro-propyl]-6-methoxy-2,4-dimethyl-phenol

2-(tert-Butyl-dimethyl-silanyloxy)-4-[2-(tert-butyl-dimethyl-silanyloxy)-3-nitro-propyl]-1-methoxy-3,5-dimethyl-benzene

1-(3-hydroxy-4-methoxy-2,6-dimethylphenyl)-3-nitro-2-propanol