3'-HYDROXYFLAVONE

Base Information

• Chemical Name: 3'-HYDROXYFLAVONE
• CAS No.: 70460-18-3
• Molecular Formula: C15H10O3
• Molecular Weight: 238.243
• Hs Code.: 2932999099
• Mol file: 70460-18-3.mol

Synonyms:3'-OH-flavone;3'-hydroxyflavone;3'-Hydroxyflavon;

Chemical Property of 3'-HYDROXYFLAVONE

Chemical Property:

• Vapor Pressure: 2.86E-08mmHg at 25°C
• Melting Point: 206-208oC
• Boiling Point: 437.7°Cat760mmHg
• PKA: 9.01±0.10(Predicted)
• Flash Point: 170.9°C
• PSA: 50.44000
• Density: 1.34g/cm³
• LogP: 3.16560

Purity/Quality:

99%min. ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-HYDROXYFLAVONE

There total 26 articles about 3'-HYDROXYFLAVONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2',3-dihydroxy-αβ-dihydrochalcone (75848-97-4) → 3'-hydroxyflavone (70460-18-3)

Guidance literature:

With palladium(II) trifluoroacetate; 5-Nitro-1,10-phenanthroline; oxygen; In dimethyl sulfoxide; at 100 ℃; for 48h;

DOI:10.1039/d1ra01672e

Reference yield: 86.0%

3'-methoxyflavone (53906-83-5) → 3'-hydroxyflavone (70460-18-3)

Guidance literature:

With boron tribromide; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00025a011

Reference yield: 85.0%

3'-Hydroxyflavanone (92496-65-6) → 3'-hydroxyflavone (70460-18-3)

Guidance literature:

With triphenylphosphine hydrobromide; dimethyl sulfoxide; at 50 ℃; for 5h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/acs.joc.5b00846

upstream raw materials:

3'-methoxyflavone

2-<(3-methoxybenzoyl)oxy>acetophenone

m-anisoyl chloride

3-Methoxybenzoic acid

Refernces

• 1、 Nagayoshi, Haruna,Murayama, Norie,Tsujino, Masaki,Takenaka, Shigeo,Katahira, Jun,Kim, Vitchan,Kim, Donghak,Komori, Masayuki,Yamazaki, Hiroshi,Guengerich, F. Peter,Shimada, Tsutomu. "Preference for O-demethylation reactions in the oxidation of 2′-, 3′-, and 4′-methoxyflavones by human cytochrome P450 enzymes". . p. 1158 - 1169. Retrieved 2020/05/11.
• 2、 An, Ji-Young,Lee, Hwi-Ho,Shin, Ji-Sun,Yoo, Hyung-Seok,Park, Jong Seon,Son, Seung Hwan,Kim, Sang Won,Yu, Jihyun,Lee, Jun,Lee, Kyung-Tae,Kim, Nam-Jung. "Identification and structure activity relationship of novel flavone derivatives that inhibit the production of nitric oxide and PGE2 in LPS-induced RAW 264.7 cells". . p. 2613 - 2616. Retrieved 2017/05/10.