ethyl 4-[2-(difluoromethoxy)phenyl]-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate

Base Information

Chemical Name:ethyl 4-[2-(difluoromethoxy)phenyl]-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
CAS No.:112024-97-2
Molecular Formula:C₁₅H₁₆F₂N₂O₄
Molecular Weight:326.3
Hs Code.:
DSSTox Substance ID:DTXSID00920653
Mol file:112024-97-2.mol

Synonyms:BRN 5613602;112024-97-2;5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(2-(difluoromethoxy)phenyl)-6-methyl-2-oxo-,ethyl ester;ethyl 4-[2-(difluoromethoxy)phenyl]-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate;DTXSID00920653;AKOS000540662;AKOS016378548;LS-134879;Z47751396;Ethyl 6-[2-(difluoromethoxy)phenyl]-2-hydroxy-4-methyl-1,6-dihydropyrimidine-5-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 4-[2-(difluoromethoxy)phenyl]-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate

Chemical Property:

Vapor Pressure:7.37E-07mmHg at 25°C
Melting Point:155-156 °C(Solv: ethanol (64-17-5))
Boiling Point:407.8°Cat760mmHg
PKA:11.22±0.70(Predicted)
Flash Point:200.4°C
PSA：80.15000
Density:1.265g/cm³
LogP:2.44780
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:6
Exact Mass:326.10781332
Heavy Atom Count:23
Complexity:496

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(NC(=O)NC1C2=CC=CC=C2OC(F)F)C

Technology Process of ethyl 4-[2-(difluoromethoxy)phenyl]-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate

There total 1 articles about ethyl 4-[2-(difluoromethoxy)phenyl]-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.8%