(1R,2R)-2-CYCLOPROPYLAMINO CYCLOHEXANOL

Base Information

• Chemical Name: (1R,2R)-2-CYCLOPROPYLAMINO CYCLOHEXANOL
• CAS No.: 189362-43-4
• Molecular Formula: C9H17NO
• Molecular Weight: 155.24
• Mol file: 189362-43-4.mol

Synonyms:

Chemical Property of (1R,2R)-2-CYCLOPROPYLAMINO CYCLOHEXANOL

Chemical Property:

• Boiling Point: 261.8±33.0 °C(Predicted)
• PKA: 14.99±0.40(Predicted)
• PSA: 32.26000
• Density: 1.05±0.1 g/cm3(Predicted)
• LogP: 1.43280
• Storage Temp.: 2-8°C

Purity/Quality:

99.90% ^*data from raw suppliers

(1R,2R)-2-(Cyclopropylamino)cyclohexanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,2R)-2-CYCLOPROPYLAMINO CYCLOHEXANOL

There total 5 articles about (1R,2R)-2-CYCLOPROPYLAMINO CYCLOHEXANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(S)-Hydroxy-phenyl-acetic acid (1R,2R)-2-cyclopropylamino-cyclohexyl ester (189362-41-2) → (1R,2R)-2-(cyclopropylamino)cyclohexan-1-ol (189362-43-4)

Guidance literature:

With potassium hydroxide; In ethanol;

DOI:10.1016/S0960-894X(98)00246-7

Reference yield: 38.0%

C9H17NO → (1R,2R)-2-(cyclopropylamino)cyclohexan-1-ol (189362-43-4)

Guidance literature:

C₉H₁₇NO; With (2E)-but-2-enedioic acid; In isopropyl alcohol; at 40 ℃;

With potassium hydroxide; In water;

DOI:10.1246/bcsj.20170369

Reference yield:

cyclohexene oxide (286-20-4) + Cyclopropylamine (765-30-0) → (1S,2S)-2-Cyclopropylamino-cyclohexanol (189362-42-3) + (1R,2R)-2-(cyclopropylamino)cyclohexan-1-ol (189362-43-4)

Guidance literature:

With soy polysaccharide Soyafibe S-DN; In water; toluene; at 40 ℃; for 26h; Reagent/catalyst; Temperature; stereoselective reaction; Catalytic behavior; Inert atmosphere;

DOI:10.1246/bcsj.20170369

upstream raw materials:

(S)-Hydroxy-phenyl-acetic acid (1R,2R)-2-cyclopropylamino-cyclohexyl ester

cyclohexane-1,2-epoxide

cyclohexene oxide

Cyclopropylamine

Refernces

• 1、 Takeuchi, Yuki,Asano, Tatsuhiro,Tsuzaki, Kazuya,Wada, Koichi. "Catalytic asymmetric amination of meso-epoxide using soy polysaccharide (Soyafibe S-DN)". . p. 678 - 683. Retrieved 2018/04/20.