4-(2-Methyl-1-pyrrolidyl)-7-chloroquinoline

Base Information

Chemical Name:4-(2-Methyl-1-pyrrolidyl)-7-chloroquinoline
CAS No.:6281-58-9
Molecular Formula:C₁₄H₁₅ClN₂
Molecular Weight:246.739
Hs Code.:
NSC Number:5820
UNII:5338U255D2
Nikkaji Number:J48.223D
ChEMBL ID:CHEMBL1885668
Mol file:6281-58-9.mol

Synonyms:4-(2-methyl-1-pyrrolidyl)-7-chloroquinoline;4-MPCQ

Suppliers and Price of 4-(2-Methyl-1-pyrrolidyl)-7-chloroquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(2-Methyl-1-pyrrolidinyl)-7-chloroquinoline
5mg
$ 265.00

Crysdot
7-Chloro-4-(2-methylpyrrolidin-1-yl)quinoline 97%
25mg
$ 960.00

Crysdot
7-Chloro-4-(2-methylpyrrolidin-1-yl)quinoline 97%
10mg
$ 435.00

Chemenu
7-Chloro-4-(2-methylpyrrolidin-1-yl)quinoline 97%
10mg
$ 407.00

Alichem
7-Chloro-4-(2-methylpyrrolidin-1-yl)quinoline
25mg
$ 1008.00

Alichem
7-Chloro-4-(2-methylpyrrolidin-1-yl)quinoline
10mg
$ 478.50

Total 7 raw suppliers

Chemical Property of 4-(2-Methyl-1-pyrrolidyl)-7-chloroquinoline

Chemical Property:

Vapor Pressure:2.29E-06mmHg at 25°C
Boiling Point:392.5°C at 760 mmHg
PKA:7.70±0.50(Predicted)
Flash Point:191.2°C
PSA：16.13000
Density:1.214g/cm³
LogP:3.94190
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:246.0923762
Heavy Atom Count:17
Complexity:271

Purity/Quality:

97% ^*data from raw suppliers

4-(2-Methyl-1-pyrrolidinyl)-7-chloroquinoline ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1CCCN1C2=C3C=CC(=CC3=NC=C2)Cl
Uses 7-Chloro-4-(2-methyl-1-pyrrolidinyl)-quinoline is a Chloroquine (C380315), iimpurity. Chloroquine is used in the treatment of malaria and MDR-strains.

Technology Process of 4-(2-Methyl-1-pyrrolidyl)-7-chloroquinoline

There total 5 articles about 4-(2-Methyl-1-pyrrolidyl)-7-chloroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6281-58-9
4-(2-methyl-1-pyrrolidyl)-7-chloroquinoline

Guidance literature:: at 60 - 65 ℃;

Reference yield:

: (4-bromo-1-methyl-butyl)-(7-chloro-[4]quinolyl)-amine

: 6281-58-9
4-(2-methyl-1-pyrrolidyl)-7-chloroquinoline

Guidance literature:: at 60 - 65 ℃; Erwaermen;

Reference yield:

: 54-05-7
Chloroquine

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 6281-58-9
4-(2-methyl-1-pyrrolidyl)-7-chloroquinoline

: 7-chloro-4-(4'-N-ethyl-N-2,2,2-trichloroethoxycarbonylamino-1'-methylbutylamino)quinoline

Guidance literature:: With sodium hydride; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, reflux, 2 h, 2.) THF, r.t., 20 min; THF, reflux, 18 h;
DOI:10.1055/s-1995-3886