Tyrosine, 2,3-dihydroxy-O-methyl-N-[3-(trifluoromethyl)benzoyl]-, methyl ester

Base Information

Chemical Name:Tyrosine, 2,3-dihydroxy-O-methyl-N-[3-(trifluoromethyl)benzoyl]-, methyl ester
CAS No.:189700-13-8
Molecular Formula:C₁₉H₁₈F₃NO₆
Molecular Weight:413.35
Hs Code.:
Mol file:189700-13-8.mol

Synonyms:

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Chemical Property of Tyrosine, 2,3-dihydroxy-O-methyl-N-[3-(trifluoromethyl)benzoyl]-, methyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Tyrosine, 2,3-dihydroxy-O-methyl-N-[3-(trifluoromethyl)benzoyl]-, methyl ester

There total 9 articles about Tyrosine, 2,3-dihydroxy-O-methyl-N-[3-(trifluoromethyl)benzoyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (Z)-3-(2,3-Bis-benzyloxy-4-methoxy-phenyl)-2-(3-trifluoromethyl-benzoylamino)-acrylic acid methyl ester

: 189700-13-8
methyl 3-(2,3-dihydroxy-4-methoxyphenyl)-2-[3-(trifluoromethyl)benzamido]propanoate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; Yield given; Ambient temperature;
DOI:10.1016/S0040-4039(97)00467-X

Reference yield:

: 109971-66-6
2,3-bis<(tert-butyldimethylsilyl)oxy>-4-methoxybenzaldehyde

: 189700-13-8
methyl 3-(2,3-dihydroxy-4-methoxyphenyl)-2-[3-(trifluoromethyl)benzamido]propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium tetrahydroborate; ethanol / 0.5 h / 0 - 20 °C

2: phosphorus tribromide / dichloromethane / 15 h / 0 °C / Inert atmosphere

3: sodium t-butanolate / toluene / 15 h / 0 - 20 °C / Inert atmosphere

4: Methanesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

5: dirhodium tetraacetate / toluene / 20 h / 80 °C / Inert atmosphere

6: sodium periodate; ruthenium trichloride / ethyl acetate; water / 20 °C

7: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 0.02 h / 0 °C

With ruthenium trichloride; dirhodium tetraacetate; sodium tetrahydroborate; sodium periodate; ethanol; tetrabutyl ammonium fluoride; phosphorus tribromide; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; Methanesulfonyl azide; sodium t-butanolate; In tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1016/j.tet.2020.131619

Reference yield:

: 1116460-22-0
{2,3-bis[(tert-butyldimethylsilyl)oxy]-4-methoxyphenyl}methanol

: 189700-13-8
methyl 3-(2,3-dihydroxy-4-methoxyphenyl)-2-[3-(trifluoromethyl)benzamido]propanoate

Guidance literature:: Multi-step reaction with 6 steps

1: phosphorus tribromide / dichloromethane / 15 h / 0 °C / Inert atmosphere

2: sodium t-butanolate / toluene / 15 h / 0 - 20 °C / Inert atmosphere

3: Methanesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

4: dirhodium tetraacetate / toluene / 20 h / 80 °C / Inert atmosphere

5: sodium periodate; ruthenium trichloride / ethyl acetate; water / 20 °C

6: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 0.02 h / 0 °C

With ruthenium trichloride; dirhodium tetraacetate; sodium periodate; tetrabutyl ammonium fluoride; phosphorus tribromide; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; Methanesulfonyl azide; sodium t-butanolate; In tetrahydrofuran; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1016/j.tet.2020.131619