1,2-Ethanediamine, N-[[(1R,2R,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]oct- 2-yl]methyl]-N,N'-bis[2-[[(4-methoxyphenyl)methyl]thio]ethyl]-

Base Information

Chemical Name:1,2-Ethanediamine, N-[[(1R,2R,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]oct- 2-yl]methyl]-N,N'-bis[2-[[(4-methoxyphenyl)methyl]thio]ethyl]-
CAS No.:189950-09-2
Molecular Formula:C37H50ClN3O2S2
Molecular Weight:668.408
Hs Code.:

1,2-Ethanediamine,
N-[[(1R,2R,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]oct-
2-yl]methyl]-N,N'-bis[2-[[(4-methoxyphenyl)methyl]thio]ethyl]-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,2-Ethanediamine, N-[[(1R,2R,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]oct- 2-yl]methyl]-N,N'-bis[2-[[(4-methoxyphenyl)methyl]thio]ethyl]-

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Technology Process of 1,2-Ethanediamine, N-[[(1R,2R,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]oct- 2-yl]methyl]-N,N'-bis[2-[[(4-methoxyphenyl)methyl]thio]ethyl]-

There total 7 articles about 1,2-Ethanediamine, N-[[(1R,2R,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]oct- 2-yl]methyl]-N,N'-bis[2-[[(4-methoxyphenyl)methyl]thio]ethyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 189950-07-0
2-{[(1R,2R,3S,5S)-3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-ylmethyl]-[2-(4-methoxy-benzylsulfanyl)-ethyl]-amino}-N-[2-(4-methoxy-benzylsulfanyl)-ethyl]-acetamide

: 189950-09-2
N-[(1R,2R,3S,5S)-3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-ylmethyl]-N,N'-bis-[2-(4-methoxy-benzylsulfanyl)-ethyl]-ethane-1,2-diamine

Guidance literature:: With borane-THF; for 12h; Heating;
DOI:10.1021/jm960532j

Reference yield:

: 22876-64-8
2?((4?methoxybenzyl)thio)ethan?1?amine

: 189950-09-2
N-[(1R,2R,3S,5S)-3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-ylmethyl]-N,N'-bis-[2-(4-methoxy-benzylsulfanyl)-ethyl]-ethane-1,2-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / -78 - 20 °C

2: 53 percent / Et₃N / acetonitrile / 12 h / Heating

3: 71 percent / BH₃*THF / 12 h / Heating

With borane-THF; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jm960532j

Reference yield:

: 189949-97-1
3β-(4'-chlorophenyl)tropane-2β-carboxylic acid chloride

: 189950-09-2
N-[(1R,2R,3S,5S)-3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]oct-2-ylmethyl]-N,N'-bis-[2-(4-methoxy-benzylsulfanyl)-ethyl]-ethane-1,2-diamine

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 6 h / Ambient temperature

2: 79 percent / BH₃*THF / 12 h / Heating

3: 53 percent / Et₃N / acetonitrile / 12 h / Heating

4: 71 percent / BH₃*THF / 12 h / Heating

With borane-THF; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1021/jm960532j