8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-chlorophenyl)-8-methyl-, (1R,2S,3S,5S)-

Base Information

Chemical Name:8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-chlorophenyl)-8-methyl-, (1R,2S,3S,5S)-
CAS No.:140633-58-5
Molecular Formula:C15H18ClNO2
Molecular Weight:279.766
Hs Code.:
Mol file:140633-58-5.mol

Synonyms:(1R,2S,3S,5S)-3-(4-Chloro-phenyl)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid;3β-(4-chlorophenyl)tropane-2β-carboxylic acid;2β-carboxylic acid-3β-(4-chlorophenyl)tropane;N-methyl-3β-(4-chlorophenyl)tropane-2β-carboxylic acid;RTI-4229-70;RTI 70;3β-(4'-chlorophenyl)tropane-2β-carboxylic acid;

Suppliers and Price of 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-chlorophenyl)-8-methyl-, (1R,2S,3S,5S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
RTI70
100mg
$ 780.00

TRC
RTI70
50mg
$ 400.00

Total 0 raw suppliers

Chemical Property of 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-chlorophenyl)-8-methyl-, (1R,2S,3S,5S)-

Chemical Property:

Boiling Point:424.4±45.0 °C(Predicted)
PSA：40.54000
Density:1.257±0.06 g/cm3(Predicted)
LogP:2.92880

Purity/Quality:: RTI70 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses RTI 70 is a cocaine derivative that prevent cocaine and MK-801 inhibition of nicotinic acetylcholine receptor (nAChR). Also, it is an intermediate used in the synthesis of RTI-113 (R701110), which is a 3-phenyltropane analogue that acts as a potent and selective dopamine uptake inhibitor. RTI-113 has been shown to reduce cocaine self-administration at high occupancy of dopamine transporter. Studies suggest that RTI-113 and its analogs may be useful tools for developing potential agonist therapies for cocaine dependence.

Technology Process of 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-chlorophenyl)-8-methyl-, (1R,2S,3S,5S)-

There total 7 articles about 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 3-(4-chlorophenyl)-8-methyl-, (1R,2S,3S,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 130342-80-2
2β-carbomethoxy-3β-(4-chlorophenyl)tropane

: 140633-58-5
3β-(4-Chlorophenyl)-tropane-2β-carboxylic acid

Guidance literature:: With water; In 1,4-dioxane; for 72h; Heating;
DOI:10.1021/jm9902234

Reference yield:

: 50373-10-9
methyl ecgonidine

: 140633-58-5
3β-(4-Chlorophenyl)-tropane-2β-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl ether / 3 h / -20 °C

2: 92 percent / H₂O / dioxane / 2 h / Heating

With water; In 1,4-dioxane; diethyl ether;
DOI:10.1016/S0960-894X(01)00625-4

Reference yield:

: 53-21-4
(-)-cocaine hydrochloride

: 140633-58-5
3β-(4-Chlorophenyl)-tropane-2β-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / water / 1 h / Reflux

2: trichlorophosphate / 4 h / Reflux

3: ammonium hydroxide / water / pH 9

4: tert-butyl methyl ether / 3 h / -40 °C

5: water / 1,4-dioxane / 24 h / Reflux

With hydrogenchloride; ammonium hydroxide; water; trichlorophosphate; In 1,4-dioxane; tert-butyl methyl ether; water;
DOI:10.1039/c4ob02165g