1,2,4-Butanetricarboxylic acid, 1-phenyl-

Base Information

• Chemical Name: 1,2,4-Butanetricarboxylic acid, 1-phenyl-
• CAS No.: 190271-89-7
• Molecular Formula: C₁₃H₁₄O₆
• Molecular Weight: 266.251
• Mol file: 190271-89-7.mol

Synonyms:

Chemical Property of 1,2,4-Butanetricarboxylic acid, 1-phenyl-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2,4-Butanetricarboxylic acid, 1-phenyl-

There total 7 articles about 1,2,4-Butanetricarboxylic acid, 1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde (100-52-7) → 1-phenyl-butane-1,2,4-tricarboxylic acid (190271-89-7)

Guidance literature:

Multi-step reaction with 4 steps

1: piperidine / ethanol / 35 - 65 °C

2: 1 h / 35 - 80 °C

3: 5 h / 35 - 80 °C

4: aq. HCl / 48 h / Heating

With piperidine; hydrogenchloride; In ethanol;

DOI:10.1016/j.bmcl.2006.06.035

Reference yield:

2-cyano-2-(cyano-phenyl-methyl)-glutaric acid diethyl ester (873380-10-0) → 1-phenyl-butane-1,2,4-tricarboxylic acid (190271-89-7)

Guidance literature:

With sulfuric acid; optically inactive substances of uncertain configurative homogeneity;

Reference yield:

ethyl 2,3-dicyano-3-phenylpropanoate (5473-13-2) → 1-phenyl-butane-1,2,4-tricarboxylic acid (190271-89-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 5 h / 35 - 80 °C

2: aq. HCl / 48 h / Heating

With hydrogenchloride;

DOI:10.1016/j.bmcl.2006.06.035

upstream raw materials:

2-cyano-2-(cyano-phenyl-methyl)-glutaric acid diethyl ester

ethyl 2,3-dicyano-3-phenylpropanoate

ethyl 3-chloropropanoate

ethyl benzylidenecyanoacetate

Downstream raw materials:

1-phenyl-butane-1,2,4-tricarboxylic acid trimethyl ester

trans-(+/-)-2-Phenylcyclopentan-3-one-1-carboxylic acid

[(1S,2R,3R)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-phenyl-cyclopentyl]-carbamic acid (S)-1-phenyl-ethyl ester

[(1R,2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-phenyl-cyclopentyl]-carbamic acid (S)-1-phenyl-ethyl ester