4-(4-Hydroxy-2-methylphenyl)butanoic acid

Base Information

• Chemical Name: 4-(4-Hydroxy-2-methylphenyl)butanoic acid
• CAS No.: 19143-95-4
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• DSSTox Substance ID: DTXSID00533045
• Wikidata: Q82406096
• Mol file: 19143-95-4.mol

Synonyms:19143-95-4;4-(4-HYDROXY-2-METHYLPHENYL)BUTANOIC ACID;DTXSID00533045;gamma-(4-Hydroxy-2-methylphenyl)buttersaure

Chemical Property of 4-(4-Hydroxy-2-methylphenyl)butanoic acid

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 194.094294304
• Heavy Atom Count: 14
• Complexity: 191

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CC(=C1)O)CCCC(=O)O

Technology Process of 4-(4-Hydroxy-2-methylphenyl)butanoic acid

There total 4 articles about 4-(4-Hydroxy-2-methylphenyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

γ-(2-methyl-4-methoxyphenyl)butyric acid (6307-30-8) → 4-(4-hydroxy-2-methylphenyl)butanoic acid (19143-95-4)

Guidance literature:

With hydrogen bromide; acetic acid;

Reference yield:

4-(4-methoxy-2-methylphenyl)-4-oxo-but-1-oic acid (67405-48-5) → 4-(4-hydroxy-2-methylphenyl)butanoic acid (19143-95-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / amalgamated zinc, conc. HCl / H₂O; toluene / 50 h / Heating

2: 60 percent / HBr-HOAc

With hydrogenchloride; amalgamated zinc; hydrogen bromide; acetic acid; In water; toluene;

Reference yield:

1-methoxy-3-methyl-benzene (100-84-5) → 4-(4-hydroxy-2-methylphenyl)butanoic acid (19143-95-4)

Guidance literature:

Multi-step reaction with 3 steps

1: succinoylation

2: 40 percent / amalgamated zinc, conc. HCl / H₂O; toluene / 50 h / Heating

3: 60 percent / HBr-HOAc

With hydrogenchloride; amalgamated zinc; hydrogen bromide; acetic acid; In water; toluene;

upstream raw materials:

γ-(2-methyl-4-methoxyphenyl)butyric acid

4-(4-methoxy-2-methylphenyl)-4-oxo-but-1-oic acid

1-methoxy-3-methyl-benzene

Downstream raw materials:

γ-(4-Hydroxy-2-methyl-phenyl)-buttersaeure-methylester

4-(4-Hydroxy-2-methyl-phenyl)-butanol-⁽¹⁾