7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(5-hydroxy-2-methoxyphenyl)methyl]-6-methoxy-, (S)-

Base Information

Chemical Name:7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(5-hydroxy-2-methoxyphenyl)methyl]-6-methoxy-, (S)-
CAS No.:192190-44-6
Molecular Formula:C18H21NO4
Molecular Weight:315.369
Hs Code.:

Synonyms:

Suppliers and Price of 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(5-hydroxy-2-methoxyphenyl)methyl]-6-methoxy-, (S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(5-hydroxy-2-methoxyphenyl)methyl]-6-methoxy-, (S)-

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(5-hydroxy-2-methoxyphenyl)methyl]-6-methoxy-, (S)-

There total 12 articles about 7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[(5-hydroxy-2-methoxyphenyl)methyl]-6-methoxy-, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.9%

: 192190-43-5
(S)-1-(5-benzyloxy-2-methoxybenzyl)-N-((S)-phenylethyl)-7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 192190-44-6
(S)-1-(5-hydroxy-2-methoxybenzyl)-7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 23h; Ambient temperature;
DOI:10.3987/com-97-7782

Reference yield:

: 52329-05-2
5-benzyloxy-2-methoxyphenyl methanol

: 192190-44-6
(S)-1-(5-hydroxy-2-methoxybenzyl)-7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 8 steps

1: 87.4 percent / SOCl₂, N,N-dimethylaniline / benzene / 1 h / 100 °C

2: 95.1 percent / dimethylsulfoxide / 1 h / 40 - 50 °C

3: 84.9 percent / 25percent ethanolic KOH / bis-(2-hydroxy-ethyl) ether / 21 h

4: SOCl₂ / benzene

5: 88.9 percent / 5percent aq. Na₂CO₃ / diethyl ether / 2 h / 0 - 5 °C

6: POCl₃ / toluene / 3.5 h / Heating

7: NaBH₄ / methanol / 2 h / -78 °C

8: 84.9 percent / H₂, conc. HCl / 10percent Pd/C / ethanol / 23 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; thionyl chloride; hydrogen; sodium carbonate; N,N-dimethyl-aniline; trichlorophosphate; palladium on activated charcoal; In methanol; diethyl ether; ethanol; dimethyl sulfoxide; toluene; diethylene glycol; benzene;
DOI:10.3987/com-97-7782

Reference yield:

: 29973-91-9
4-benzyloxy-3-methoxyphenylacetic acid

: 192190-44-6
(S)-1-(5-hydroxy-2-methoxybenzyl)-7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂

2: 82.8 percent / 5percent aq. Na₂CO₃ / diethyl ether / 1 h / 0 - 5 °C

3: 87 percent / 47percent BF₃*ether, 1.0M BH₃*THF / tetrahydrofuran / 2.5 h / 70 °C

4: 88.9 percent / 5percent aq. Na₂CO₃ / diethyl ether / 2 h / 0 - 5 °C

5: POCl₃ / toluene / 3.5 h / Heating

6: NaBH₄ / methanol / 2 h / -78 °C

7: 84.9 percent / H₂, conc. HCl / 10percent Pd/C / ethanol / 23 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; borane-THF; boron trifluoride diethyl etherate; hydrogen; sodium carbonate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethanol; toluene;
DOI:10.3987/com-97-7782