(S)-1-(5-benzyloxy-2-methoxybenzyl)-N-((S)-phenylethyl)-7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:(S)-1-(5-benzyloxy-2-methoxybenzyl)-N-((S)-phenylethyl)-7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:192190-43-5
Molecular Formula:C₄₀H₄₁NO₄
Molecular Weight:599.77
Hs Code.:

Synonyms:(S)-1-(5-benzyloxy-2-methoxybenzyl)-N-((S)-phenylethyl)-7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline

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Chemical Property of (S)-1-(5-benzyloxy-2-methoxybenzyl)-N-((S)-phenylethyl)-7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline

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Technology Process of (S)-1-(5-benzyloxy-2-methoxybenzyl)-N-((S)-phenylethyl)-7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline

There total 9 articles about (S)-1-(5-benzyloxy-2-methoxybenzyl)-N-((S)-phenylethyl)-7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 192190-42-4
7-Benzyloxy-1-(5-benzyloxy-2-methoxy-benzyl)-6-methoxy-2-((S)-1-phenyl-ethyl)-3,4-dihydro-isoquinolinium

: 192190-43-5
(S)-1-(5-benzyloxy-2-methoxybenzyl)-N-((S)-phenylethyl)-7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium tetrahydroborate; In methanol; at -78 ℃; for 2h; Yield given;
DOI:10.3987/com-97-7782

Reference yield:

: 52329-05-2
5-benzyloxy-2-methoxyphenyl methanol

: 192190-43-5
(S)-1-(5-benzyloxy-2-methoxybenzyl)-N-((S)-phenylethyl)-7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 7 steps

1: 87.4 percent / SOCl₂, N,N-dimethylaniline / benzene / 1 h / 100 °C

2: 95.1 percent / dimethylsulfoxide / 1 h / 40 - 50 °C

3: 84.9 percent / 25percent ethanolic KOH / bis-(2-hydroxy-ethyl) ether / 21 h

4: SOCl₂ / benzene

5: 88.9 percent / 5percent aq. Na₂CO₃ / diethyl ether / 2 h / 0 - 5 °C

6: POCl₃ / toluene / 3.5 h / Heating

7: NaBH₄ / methanol / 2 h / -78 °C

With potassium hydroxide; sodium tetrahydroborate; thionyl chloride; sodium carbonate; N,N-dimethyl-aniline; trichlorophosphate; In methanol; diethyl ether; dimethyl sulfoxide; toluene; diethylene glycol; benzene;
DOI:10.3987/com-97-7782

Reference yield:

: 54313-35-8
2-(4-(benzyloxy)-3-methoxyphenyl)acetyl chloride

: 192190-43-5
(S)-1-(5-benzyloxy-2-methoxybenzyl)-N-((S)-phenylethyl)-7-benzyloxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 82.8 percent / 5percent aq. Na₂CO₃ / diethyl ether / 1 h / 0 - 5 °C

2: 87 percent / 47percent BF₃*ether, 1.0M BH₃*THF / tetrahydrofuran / 2.5 h / 70 °C

3: 88.9 percent / 5percent aq. Na₂CO₃ / diethyl ether / 2 h / 0 - 5 °C

4: POCl₃ / toluene / 3.5 h / Heating

5: NaBH₄ / methanol / 2 h / -78 °C

With sodium tetrahydroborate; borane-THF; boron trifluoride diethyl etherate; sodium carbonate; trichlorophosphate; In tetrahydrofuran; methanol; diethyl ether; toluene;
DOI:10.3987/com-97-7782