2-Butenoic acid, 4,4-dimethoxy-, ethyl ester

Base Information

• Chemical Name: 2-Butenoic acid, 4,4-dimethoxy-, ethyl ester
• CAS No.: 19255-60-8
• Molecular Formula: C₈H₁₄O₄
• Molecular Weight: 174.197
• Mol file: 19255-60-8.mol

Synonyms:4,4-dimethoxy-but-2-enoic acid ethyl ester;ethyl (E)-4,4-dimethoxy-but-2-enoate;Ethyl (E)-4,4-dimethoxy-2-butenoate;

Chemical Property of 2-Butenoic acid, 4,4-dimethoxy-, ethyl ester

Chemical Property:

• PSA: 44.76000
• LogP: 0.72460

Purity/Quality:

95%-98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Butenoic acid, 4,4-dimethoxy-, ethyl ester

There total 3 articles about 2-Butenoic acid, 4,4-dimethoxy-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + dimethoxyacetaldehyde (51673-84-8) → (E)-4,4-dimethoxy-but-2-enoic acid ethyl ester (19255-60-8,114736-26-4,114736-25-3)

Guidance literature:

With potassium carbonate; In water; toluene; for 2h; optical yield given as %de; Reflux;

DOI:10.1039/c2cc33309k

Reference yield: 82.0%

ethanol (64-17-5) + (2E)-4,4-dimethoxybut-2-enal (18778-96-6,4093-49-6) → (E)-4,4-dimethoxy-but-2-enoic acid ethyl ester (19255-60-8,114736-26-4,114736-25-3)

Guidance literature:

With manganese(IV) oxide; sodium cyanide; acetic acid; at 20 ℃; for 24h;

Reference yield:

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + dimethoxyacetaldehyde (51673-84-8) → (Z)-4,4-Dimethoxy-but-2-enoic acid ethyl ester (114736-26-4) + (E)-4,4-dimethoxy-but-2-enoic acid ethyl ester (19255-60-8,114736-26-4,114736-25-3)

Guidance literature:

With potassium carbonate; In cyclohexane; Yield given. Yields of byproduct given; Heating;

DOI:10.1016/S0040-4039(00)96713-3

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

dimethoxyacetaldehyde

ethanol

(2E)-4,4-dimethoxybut-2-enal

Downstream raw materials:

6-Dimethoxymethyl-4-ethoxy-2-oxo-cyclohex-3-enecarboxylic acid ethyl ester

ethyl 2-(6-bromoimidazo[1,2-a]pyridin-3-yl)-acetate

imidazo[1,2-α]pyridin-3-yl-acetic acid ethyl ester

4-oxo-but-2-enoic acid ethyl ester