7-Nitronaphthalen-1-ol

Base Information

• Chemical Name: 7-Nitronaphthalen-1-ol
• CAS No.: 19256-82-7
• Molecular Formula: C10H7NO3
• Molecular Weight: 189.16700
• European Community (EC) Number: 878-161-9
• DSSTox Substance ID: DTXSID70528862
• Nikkaji Number: J886.543D
• Wikidata: Q82398808
• Mol file: 19256-82-7.mol

Synonyms:7-Nitronaphthalen-1-ol;19256-82-7;1-Hydroxy-7-nitronaphthalene;1-Naphthalenol, 7-nitro-;SCHEMBL4958995;DTXSID70528862;AKOS024438788;EN300-1143462

Chemical Property of 7-Nitronaphthalen-1-ol

Chemical Property:

• PSA: 66.05000
• LogP: 2.97680
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 189.042593085
• Heavy Atom Count: 14
• Complexity: 226

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=C(C=C2)[N+](=O)[O-])C(=C1)O

Technology Process of 7-Nitronaphthalen-1-ol

There total 12 articles about 7-Nitronaphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

7-nitro-3,4-dihydro-2H-naphthalen-1-one (40353-34-2) → 7-nitronaphthalen-1-ol (19256-82-7)

Guidance literature:

With palladium 10% on activated carbon; potassium carbonate; In N,N-dimethyl acetamide; at 165 ℃; for 2h;

DOI:10.1021/acs.joc.0c02346

Reference yield:

1-Fluoro-7-nitronaphthalin (13720-46-2) → 7-nitronaphthalen-1-ol (19256-82-7)

Guidance literature:

With sodium hydroxide; In acetonitrile; Irradiation;

Reference yield:

4-Nitroanthranilic acid (619-17-0) → 7-nitronaphthalen-1-ol (19256-82-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) isoamyl nitrite / 1.) CHCl₃, 15 min, reflux; 2.) dioxane 70 deg C

2: HCl / methanol / Heating

With hydrogenchloride; isopentyl nitrite; In methanol;

DOI:10.1016/S0040-4020(01)87413-5

upstream raw materials:

1-Fluoro-7-nitronaphthalin

2-furanoic acid

5-nitro-2-iodosobenzoic acid

1,4-dihydro-7-nitro-1,4-epoxynaphthalene

Downstream raw materials:

1-hydroxy-7-aminonaphthalene

1-Methoxy-7-nitronaphthalin

8-methoxy-2-naphthylamine

(Z)-3-hydroxy-1,3-diphenyl-2-propen-1-one