5-Fluoroquinazoline-2,4(1H,3H)-dione

Base Information

• Chemical Name: 5-Fluoroquinazoline-2,4(1H,3H)-dione
• CAS No.: 192570-33-5
• Molecular Formula: C8H5FN2O2
• Molecular Weight: 180.13600
• Hs Code.: 2933990090
• Mol file: 192570-33-5.mol

Synonyms:2,4(1H,3H)-quinazolinedione,5-fluoro;5-fluoroquinazoline-2,4-(1H,3H)-dione;5-Fluoroquinazoline-2,4(1H,3H)-dione;

Chemical Property of 5-Fluoroquinazoline-2,4(1H,3H)-dione

Chemical Property:

• Melting Point: 320-322℃ (ethanol )
• PKA: 9?+-.0.20(Predicted)
• PSA: 66.24000
• Density: 1.434±0.06 g/cm3(Predicted)
• LogP: 1.18010
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

5-Fluoroquinazoline-2,4(1H,3H)-dione 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoroquinazoline-2,4(1H,3H)-dione

There total 9 articles about 5-Fluoroquinazoline-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.8%

2-amino-6-fluorobenzonitrile (77326-36-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 5-fluoro-1H-quinazoline-2,4(1H,3H)-dione (192570-33-5)

Guidance literature:

With carbon dioxide; In water; at 150 ℃; for 5h; under 37503.8 Torr;

DOI:10.1021/acs.oprd.6b00244

Reference yield: 91.5%

2-amino-6-fluorobenzoic acid (434-76-4) + sodium isocyanate (917-61-3) → 5-fluoro-1H-quinazoline-2,4(1H,3H)-dione (192570-33-5)

Guidance literature:

2-amino-6-fluorobenzoic acid; With acetic acid; In water; at 35 ℃; for 0.25h;

sodium isocyanate; In water; at 35 ℃; for 0.5h;

Reference yield: 84.0%

2-amino-6-fluorobenzoic acid (434-76-4) + urea (57-13-6) → 5-fluoro-1H-quinazoline-2,4(1H,3H)-dione (192570-33-5)

Guidance literature:

With sodium hydroxide; In water; for 72h; Heating;

DOI:10.1016/S0040-4020(97)00564-4

upstream raw materials:

2-amino-6-fluorobenzoic acid

urea

2-amino-6-fluorobenzonitrile

carbon dioxide

Downstream raw materials:

1-(3,5-di-O-p-toluoyl-2-deoxy-α,β-D-erythro-pentofuranosyl)-5-fluoro-quinazoline-2,4(3H)-dione

2,4-dichloro-5-fluoroquinazoline

2-((2-chloro-5-fluoro-4-oxoquinazolin-3(4H)-yl)methyl)benzonitrile

1-[2-deoxy-5-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl]-5-fluoro-quinazoline-2,4(3H)-dione