Chemical Property of 2-Phenylethynesulfonamide
Chemical Property:
- Vapor Pressure:4.03E-05mmHg at 25°C
- Melting Point:135.0 to 139.0 °C
- Refractive Index:1.633
- Boiling Point:351.7 °C at 760 mmHg
- PKA:7.96±0.60(Predicted)
- Flash Point:166.5 °C
- PSA：68.54000
- Density:1.39 g/cm3
- LogP:2.06520
- Storage Temp.:2-8°C
- Solubility.:DMSO: soluble >10mg/mL, clear
- XLogP3:1.1
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:1
- Exact Mass:181.01974964
- Heavy Atom Count:12
- Complexity:295
- Purity/Quality:
-
99%, *data from raw suppliers
Phenylethynsulfonic Acid Amide *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22-36/37/38
- Safety Statements:
26
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:C1=CC=C(C=C1)C#CS(=O)(=O)N
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Description
In addition to its transactivational functions, p53 mediates apoptosis by binding with the anti-apoptotic proteins Bcl-xL and Bcl-2 at the mitochondrial surface. Pifithrin-μ (PFT-μ) is an inhibitor of p53-mediated apoptosis, preventing p53 binding to Bcl-xL and Bcl-2 at the mitochondria without affecting p53 transactivational activities In vitro, PFT-μ binds both p53 (Kd = 0.82 mM) and Bcl-xL (Kd = 0.80 mM). PFT-μ reduces p53-mediated apoptosis induced by γ-radiation in mouse thymocytes in vitro and protects mice from doses of radiation that cause lethal hematopoietic syndrome. At 25 μM, PFT-μ reduces apoptosis triggered by nutlin-3, which inhibits MDM2/p53 binding and potentiates p53-mediated growth arrest and apoptosis. PFT-μ also interacts selectively with heat shock protein 70 (Hsp70), leading to disruption of the association between Hsp70 and many of its co-chaperones and substrate proteins.
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Uses
A small molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation Pifithrin-μ has been used:to treat microglial cell line to analyse its neuroprotective effect on M1-like and M2-like phenotypeas heat shock protein (HSP)-70 inhibitor, to treat transfected Marc-145 cellsto inhibit heat shock cognate 70 (Hsc70) to elucidate heat shock chaperones mouse embryonic stem cells
