4-[(4-Diethylcarbamoyl-phenyl)-hydroxy-phenyl-methyl]-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-[(4-Diethylcarbamoyl-phenyl)-hydroxy-phenyl-methyl]-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:193217-40-2
Molecular Formula:C28H38N2O4
Molecular Weight:466.621
Hs Code.:
DSSTox Substance ID:DTXSID201114381

Synonyms:193217-40-2;1-Piperidinecarboxylic acid, 4-[[4-[(diethylamino)carbonyl]phenyl]hydroxyphenylmethyl]-, 1,1-dimethylethyl ester;DTXSID201114381;4-[(4-Diethylcarbamoyl-phenyl)-hydroxy-phenyl-methyl]-piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 4-[[4-(diethylcarbamoyl)phenyl]-hydroxy-phenylmethyl]piperidine-1-carboxylate;1,1-Dimethylethyl 4-[[4-[(diethylamino)carbonyl]phenyl]hydroxyphenylmethyl]-1-piperidinecarboxylate

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Chemical Property of 4-[(4-Diethylcarbamoyl-phenyl)-hydroxy-phenyl-methyl]-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:466.28315770
Heavy Atom Count:34
Complexity:664

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCN(CC)C(=O)C1=CC=C(C=C1)C(C2CCN(CC2)C(=O)OC(C)(C)C)(C3=CC=CC=C3)O

Technology Process of 4-[(4-Diethylcarbamoyl-phenyl)-hydroxy-phenyl-methyl]-piperidine-1-carboxylic acid tert-butyl ester

There total 3 articles about 4-[(4-Diethylcarbamoyl-phenyl)-hydroxy-phenyl-methyl]-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 77350-52-8
N,N-diethyl-4-iodobenzamide

: 193217-39-9
1-(t-butoxycarbonyl)-4-(benzoyl)piperidine

: 193217-40-2
4-(α-hydroxy-α-(4-N-tert-butoxycarbonylpiperidinyl)benzyl)-N,N-diethylbenzamide

Guidance literature:: N,N-diethyl-4-iodobenzamide; With tert.-butyl lithium; In tetrahydrofuran; hexane; at -78 ℃;

1-(t-butoxycarbonyl)-4-(benzoyl)piperidine; In tetrahydrofuran; hexane; at -78 - 20 ℃; Further stages.;
DOI:10.1021/jm000228x

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 193217-40-2
4-(α-hydroxy-α-(4-N-tert-butoxycarbonylpiperidinyl)benzyl)-N,N-diethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / KHCO₃ / tetrahydrofuran; H₂O / 1 h / Heating

2.1: t-BuLi / tetrahydrofuran; hexane / -78 °C

2.2: 94 percent / tetrahydrofuran; hexane / -78 - 20 °C

With tert.-butyl lithium; potassium hydrogencarbonate; In tetrahydrofuran; hexane; water; 1.1: Condensation / 2.1: Metallation / 2.2: Addition;
DOI:10.1021/jm000228x

Reference yield:

: 25519-80-6
4-(benzoyl)piperidine hydrochloride

: 193217-40-2
4-(α-hydroxy-α-(4-N-tert-butoxycarbonylpiperidinyl)benzyl)-N,N-diethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 98 percent / KHCO₃ / tetrahydrofuran; H₂O / 1 h / Heating

2.1: t-BuLi / tetrahydrofuran; hexane / -78 °C

2.2: 94 percent / tetrahydrofuran; hexane / -78 - 20 °C

With tert.-butyl lithium; potassium hydrogencarbonate; In tetrahydrofuran; hexane; water; 1.1: Condensation / 2.1: Metallation / 2.2: Addition;
DOI:10.1021/jm000228x