(+)-Timolol

Base Information

Chemical Name:(+)-Timolol
CAS No.:26839-76-9
Molecular Formula:C13H24 N4 O3 S
Molecular Weight:316.425
Hs Code.:2934999090
European Community (EC) Number:248-033-1
UNII:2BG20ZUO2E
DSSTox Substance ID:DTXSID801318141
Nikkaji Number:J249.057I
Wikidata:Q27120254
Metabolomics Workbench ID:56312
ChEMBL ID:CHEMBL1744069
Mol file:26839-76-9.mol

Synonyms:(R)-timolol;(+)-timolol;26839-76-9;Timolol, (+)-;d-Timolol;(R)-(+)-Timolol;(2R)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol;UNII-2BG20ZUO2E;2BG20ZUO2E;CHEBI:39466;EINECS 248-033-1;(+)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol;1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-2-propanol;(+)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol;C13-H24-N4-O3-S;R-Timolol;(2r)-1-(tert-butylamino)-3-{[4-(morpholin-4-yl)-1,2,5-thiadiazol-3-yl]oxy}propan-2-ol;Spectrum_000192;Spectrum2_001334;Spectrum3_001366;Spectrum4_001164;Spectrum5_000582;TIMOLOL, (R)-;BSPBio_002892;KBioGR_001767;KBioSS_000672;DivK1c_000178;SCHEMBL222970;SPBio_001487;CHEMBL1744069;KBio1_000178;KBio2_000672;KBio2_003240;KBio2_005808;KBio3_002112;TIMOLOL ANHYDROUS, (R)-;NINDS_000178;DTXSID801318141;AKOS030254981;IDI1_000178;NCGC00178405-01;SBI-0051535.P003;AB00053554_02;EN300-6492953;TIMOLOL MALEATE IMPURITY A [EP IMPURITY];L 714465;L-714465;BRD-K30421593-050-02-3;BRD-K30421593-050-03-1;Q27120254;2-Propanol, 1-(tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)-;(2R)-1-((1,1-DIMETHYLETHYL)AMINO)-3-((4-(MORPHOLIN-4-YL)-1,2,5-THIADIAZOL-3-YL)OXY)PROPAN-2-OL;2-PROPANOL, 1-((1,1-DIMETHYLETHYL)AMINO)-3-((4-(4-MORPHOLINYL)-1,2,5-THIADIAZOL-3-YL)OXY)-, (2R)-;2-Propanol, 1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl]oxy]-, (R)-

Suppliers and Price of (+)-Timolol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(R)-Timolol
10mg
$ 150.00

Medical Isotopes, Inc.
(R)-Timolol
100 mg
$ 2200.00

American Custom Chemicals Corporation
TIMOLOL IMPURITY A 95.00%
5MG
$ 453.59

Total 12 raw suppliers

Chemical Property of (+)-Timolol

Chemical Property:

Vapor Pressure:2.62E-10mmHg at 25°C
Boiling Point:487.2°Cat760mmHg
Flash Point:248.5°C
PSA：107.98000
Density:1.224g/cm³
LogP:0.95840
XLogP3:1.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:7
Exact Mass:316.15691181
Heavy Atom Count:21
Complexity:310

Purity/Quality:

98%, ^*data from raw suppliers

(R)-Timolol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O
Isomeric SMILES:CC(C)(C)NC[C@H](COC1=NSN=C1N2CCOCC2)O
Uses (R)-Timolol is an antihypertensive agent that increases ocular blood flow and reduces intraocular pressure. (R)-Timolol is an β-adrenergic blocking agent that binds only to nonspecific sites in the pa rticulate fraction of the heart, lungs, and brain. (R)-Timolol (Timolol EP Impurity A; Timolol BP Impurity A; Timolol USP Related Compound A) is an antihypertensive agent that increases ocular blood flow and reduces intraocular pressure. (R)-Timolol is an β-adrenergic blocking agent that binds only to nonspecific sites in the particulate fraction of the heart, lungs, and brain.

Technology Process of (+)-Timolol

There total 4 articles about (+)-Timolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29023-48-1,47148-57-2
timolol

: 26839-75-8,47148-57-2
timolol

: 26839-76-9,47148-57-2
R-(+)-1-tert-butylamino-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol

Guidance literature:: With AmyCoat (150x46 mm, 3 μm size silica particle); In ethanol; n-heptane; diethylamine; at 27 ℃; Resolution of racemate;
DOI:10.1002/chir.20697

Reference yield:

: 30165-97-0
3-hydroxy-4-(N-morpholino)-1,2,5-thiadiazole

: 67843-74-7,24969-06-0,13403-37-7
(S)-epichlorohydrin

: 75-64-9
tert-butylamine

: 26839-76-9,47148-57-2
R-(+)-1-tert-butylamino-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol

Guidance literature:: 3-hydroxy-4-(N-morpholino)-1,2,5-thiadiazole; (S)-epichlorohydrin; With sodium carbonate; In tetrahydrofuran; at 60 - 65 ℃; for 14.5h;

tert-butylamine; at 44 - 46 ℃; for 3h; Product distribution / selectivity;