4'-Fluoro-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)flavone

Base Information

Chemical Name:4'-Fluoro-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)flavone
CAS No.:86073-57-6
Molecular Formula:C₂₂H₂₂FNO₃
Molecular Weight:367.42
Hs Code.:
DSSTox Substance ID:DTXSID70235382
Nikkaji Number:J126.062F
Wikidata:Q83117272

Synonyms:4'-Fluoro-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)flavone;BRN 6002066;86073-57-6;Flavone, 4'-fluoro-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)-;4H-1-Benzopyran-4-one, 2-(4-fluorophenyl)-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)-;C22H22FNO3;DTXSID70235382;C22-H22-F-N-O3;LS-69003

Suppliers and Price of 4'-Fluoro-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)flavone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4'-Fluoro-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)flavone

Chemical Property:

Vapor Pressure:2.66E-10mmHg at 25°C
Boiling Point:504.4°Cat760mmHg
Flash Point:258.9°C
Density:1.249g/cm³
XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:367.15837173
Heavy Atom Count:27
Complexity:578

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(OC2=C(C1=O)C=CC(=C2CN3CCCC3)OC)C4=CC=C(C=C4)F

Technology Process of 4'-Fluoro-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)flavone

There total 4 articles about 4'-Fluoro-7-methoxy-3-methyl-8-(1-pyrrolidinylmethyl)flavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 123-75-1
pyrrolidine

: 86073-68-9
3-Methyl-7-methoxy-8-chloromethyl-4'-fluoroflavone

: 86073-57-6
3-Methyl-7-methoxy-8-pyrrolidinomethyl-4'-fluoroflavone

Guidance literature:: In benzene; for 48h; Ambient temperature;
DOI:10.1002/ardp.19833160507

Reference yield:

: 6270-44-6
2-hydroxy-4-methoxypropiophenone

: 86073-57-6
3-Methyl-7-methoxy-8-pyrrolidinomethyl-4'-fluoroflavone

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / sodium p-fluorobenzoate

2: 80 percent / HCl / acetic acid; aq. HCl / 5 h / 70 - 80 °C

3: 80 percent / benzene / 48 h / Ambient temperature

With hydrogenchloride; sodium 4-fluorobenzoate; In hydrogenchloride; acetic acid; benzene;
DOI:10.1002/ardp.19833160507

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 86073-57-6
3-Methyl-7-methoxy-8-pyrrolidinomethyl-4'-fluoroflavone

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / sodium p-fluorobenzoate

2: 80 percent / HCl / acetic acid; aq. HCl / 5 h / 70 - 80 °C

3: 80 percent / benzene / 48 h / Ambient temperature

With hydrogenchloride; sodium 4-fluorobenzoate; In hydrogenchloride; acetic acid; benzene;
DOI:10.1002/ardp.19833160507